Munier-Lehmann H - Search Results

1

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E. Aulner N, et al. PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2154. doi: 10.1371/journal.pntd.0002154. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23593521 Free PMC article.

2

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.

Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C. Zeidler U, et al. J Antimicrob Chemother. 2013 Jun;68(6):1285-96. doi: 10.1093/jac/dks538. Epub 2013 Feb 1. J Antimicrob Chemother. 2013. PMID: 23378416 Free article.

3

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.

Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO. Lucas-Hourani M, et al. PLoS Pathog. 2013;9(10):e1003678. doi: 10.1371/journal.ppat.1003678. Epub 2013 Oct 3. PLoS Pathog. 2013. PMID: 24098125 Free PMC article.

4

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.

Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO. Lucas-Hourani M, et al. J Vis Exp. 2014 May 5;(87):51222. doi: 10.3791/51222. J Vis Exp. 2014. PMID: 24838008 Free PMC article.

5

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL. Munier-Lehmann H, et al. J Med Chem. 2015 Jan 22;58(2):860-77. doi: 10.1021/jm501446r. Epub 2015 Jan 6. J Med Chem. 2015. PMID: 25558988

6

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].

Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H. Vidalain PO, et al. Med Sci (Paris). 2015 Jan;31(1):98-104. doi: 10.1051/medsci/20153101019. Epub 2015 Feb 6. Med Sci (Paris). 2015. PMID: 25658737 Free article. Review. French.

7

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL. Lucas-Hourani M, et al. J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30. J Med Chem. 2015. PMID: 26079043 Free PMC article.

8

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.

Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C. Raj S, et al. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1438-49. doi: 10.1128/AAC.02239-15. Antimicrob Agents Chemother. 2015. PMID: 26666917 Free PMC article.

9

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO. Khiar S, et al. Sci Rep. 2017 May 31;7(1):2561. doi: 10.1038/s41598-017-02776-z. Sci Rep. 2017. PMID: 28566766 Free PMC article.

10

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO. Lucas-Hourani M, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00383-17. doi: 10.1128/AAC.00383-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28807907 Free PMC article.

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