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Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P. Bono F, et al. Among authors: schaeffer p. Cancer Cell. 2013 Apr 15;23(4):477-88. doi: 10.1016/j.ccr.2013.02.019. Cancer Cell. 2013. PMID: 23597562 Free article.
Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: this mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs.
Fons P, Gueguen-Dorbes G, Herault JP, Geronimi F, Tuyaret J, Frédérique D, Schaeffer P, Volle-Challier C, Herbert JM, Bono F. Fons P, et al. Among authors: schaeffer p. J Cell Physiol. 2015 Jan;230(1):43-51. doi: 10.1002/jcp.24656. J Cell Physiol. 2015. PMID: 24760775
Pharmacokinetics of new synthetic heparin mimetics.
Hérault JP, Bernat A, Roye F, Michaux C, Schaeffer P, Bono F, Petitou M, Herbert JM. Hérault JP, et al. Among authors: schaeffer p. Thromb Haemost. 2002 Jun;87(6):985-9. Thromb Haemost. 2002. PMID: 12083506
284 results