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Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P. Bono F, et al. Among authors: simons m. Cancer Cell. 2013 Apr 15;23(4):477-88. doi: 10.1016/j.ccr.2013.02.019. Cancer Cell. 2013. PMID: 23597562 Free article.
Fibroblast growth factor regulation of neovascularization.
Murakami M, Simons M. Murakami M, et al. Among authors: simons m. Curr Opin Hematol. 2008 May;15(3):215-20. doi: 10.1097/MOH.0b013e3282f97d98. Curr Opin Hematol. 2008. PMID: 18391788 Free PMC article. Review.
VEGFR2 trafficking: speed doesn't kill.
Zhang X, Lanahan AA, Simons M. Zhang X, et al. Among authors: simons m. Cell Cycle. 2013 Jul 15;12(14):2163-4. doi: 10.4161/cc.25536. Cell Cycle. 2013. PMID: 23803732 Free PMC article. No abstract available.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P. Mazzone M, et al. Among authors: simons m. Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12. Cell. 2009. PMID: 19217150 Free PMC article.
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.
Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M. Lanahan AA, et al. Among authors: simons m. Dev Cell. 2010 May 18;18(5):713-24. doi: 10.1016/j.devcel.2010.02.016. Epub 2010 May 6. Dev Cell. 2010. PMID: 20434959 Free PMC article.
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. Yu P, et al. Among authors: simons m. Nature. 2017 May 11;545(7653):224-228. doi: 10.1038/nature22322. Epub 2017 May 3. Nature. 2017. PMID: 28467822 Free PMC article.
Selective regulation of arterial branching morphogenesis by synectin.
Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M. Chittenden TW, et al. Among authors: simons m. Dev Cell. 2006 Jun;10(6):783-95. doi: 10.1016/j.devcel.2006.03.012. Dev Cell. 2006. PMID: 16740480 Free article.
The FGF system has a key role in regulating vascular integrity.
Murakami M, Nguyen LT, Zhuang ZW, Moodie KL, Carmeliet P, Stan RV, Simons M. Murakami M, et al. Among authors: simons m. J Clin Invest. 2008 Oct;118(10):3355-66. doi: 10.1172/JCI35298. J Clin Invest. 2008. PMID: 18776942 Free PMC article.
1,541 results