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Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R. Williamson MG, et al. Among authors: mock ed. Hum Mol Genet. 2023 Sep 5;32(18):2808-2821. doi: 10.1093/hmg/ddad102. Hum Mol Genet. 2023. PMID: 37384414 Free PMC article.
Fluorescence-Based NAPE-PLD Activity Assay.
Mock ED, Driever WPF, van der Stelt M. Mock ED, et al. Methods Mol Biol. 2023;2576:233-240. doi: 10.1007/978-1-0716-2728-0_19. Methods Mol Biol. 2023. PMID: 36152191
Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family.
Zhou J, Mock ED, Al Ayed K, Di X, Kantae V, Burggraaff L, Stevens AF, Martella A, Mohr F, Jiang M, van der Wel T, Wendel TJ, Ofman TP, Tran Y, de Koster N, van Westen GJP, Hankemeier T, van der Stelt M. Zhou J, et al. Among authors: mock ed. J Med Chem. 2020 Sep 10;63(17):9340-9359. doi: 10.1021/acs.jmedchem.0c00522. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787138 Free PMC article.
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M. Mock ED, et al. Nat Chem Biol. 2020 Jun;16(6):667-675. doi: 10.1038/s41589-020-0528-7. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393901 Free PMC article.
Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.
Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al-Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, Hankemeier T, van Westen GJP, van der Stelt M. Zhou J, et al. Among authors: mock ed. ACS Chem Biol. 2019 Feb 15;14(2):164-169. doi: 10.1021/acschembio.8b00969. Epub 2019 Jan 18. ACS Chem Biol. 2019. PMID: 30620559 Free PMC article.
44 results