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Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling.
Konkalmatt PR, Wang F, Piras BA, Xu Y, O'Connor DM, Beyers RJ, Epstein FH, Annex BH, Hossack JA, French BA. Konkalmatt PR, et al. J Gene Med. 2012 Sep-Oct;14(9-10):609-20. doi: 10.1002/jgm.2673. J Gene Med. 2012. PMID: 23065925 Free PMC article.
Cardiac-selective expression of extracellular superoxide dismutase after systemic injection of adeno-associated virus 9 protects the heart against post-myocardial infarction left ventricular remodeling.
Konkalmatt PR, Beyers RJ, O'Connor DM, Xu Y, Seaman ME, French BA. Konkalmatt PR, et al. Circ Cardiovasc Imaging. 2013 May 1;6(3):478-86. doi: 10.1161/CIRCIMAGING.112.000320. Epub 2013 Mar 27. Circ Cardiovasc Imaging. 2013. PMID: 23536266 Free PMC article.
Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease.
Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizarro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB. Tlaxca JL, et al. Among authors: konkalmatt pr. J Control Release. 2013 Feb 10;165(3):216-25. doi: 10.1016/j.jconrel.2012.10.021. Epub 2012 Nov 8. J Control Release. 2013. PMID: 23142578 Free PMC article.
28 results