Pascual J - Search Results

1

A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states.

Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: pascual j. J Pharmacol Exp Ther. 2013 Jul;346(1):113-20. doi: 10.1124/jpet.113.204776. Epub 2013 Apr 30. J Pharmacol Exp Ther. 2013. PMID: 23633618 Free PMC article.

2

Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.

Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: pascual j. Mol Pharmacol. 2011 Dec;80(6):1047-55. doi: 10.1124/mol.111.074427. Epub 2011 Aug 29. Mol Pharmacol. 2011. PMID: 21875942 Free PMC article.

3

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: pascual j. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22909231 Free PMC article.

4

The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants.

Chan SL, Mukasa T, Santelli E, Low LY, Pascual J. Chan SL, et al. Among authors: pascual j. Protein Sci. 2010 Jan;19(1):155-61. doi: 10.1002/pro.275. Protein Sci. 2010. PMID: 19845004 Free PMC article.

5

Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins.

Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. Reixach N, et al. Among authors: pascual j. J Biol Chem. 2008 Jan 25;283(4):2098-107. doi: 10.1074/jbc.M708028200. Epub 2007 Nov 15. J Biol Chem. 2008. PMID: 18006495 Free article.

6

Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain.

Chan SL, Low LY, Hsu S, Li S, Liu T, Santelli E, Le Negrate G, Reed JC, Woods VL Jr, Pascual J. Chan SL, et al. Among authors: pascual j. J Biol Chem. 2009 Aug 7;284(32):21386-92. doi: 10.1074/jbc.C109.007591. Epub 2009 Jun 17. J Biol Chem. 2009. PMID: 19535337 Free PMC article.

7

LUD, a new protein domain associated with lactate utilization.

Hwang WC, Bakolitsa C, Punta M, Coggill PC, Bateman A, Axelrod HL, Rawlings ND, Sedova M, Peterson SN, Eberhardt RY, Aravind L, Pascual J, Godzik A. Hwang WC, et al. Among authors: pascual j. BMC Bioinformatics. 2013 Nov 26;14:341. doi: 10.1186/1471-2105-14-341. BMC Bioinformatics. 2013. PMID: 24274019 Free PMC article.

8

Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.

De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J. De Pereda JM, et al. Among authors: pascual j. J Biol Chem. 2004 Feb 27;279(9):8111-5. doi: 10.1074/jbc.M311449200. Epub 2003 Dec 5. J Biol Chem. 2004. PMID: 14660562 Free article.

9

Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31.

Mukasa T, Santelli E, Reed JC, Pascual J. Mukasa T, et al. Among authors: pascual j. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):297-9. doi: 10.1107/S1744309107008925. Epub 2007 Mar 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17401199 Free PMC article.

10

Canonical and alternative MAPK signaling.

Pimienta G, Pascual J. Pimienta G, et al. Among authors: pascual j. Cell Cycle. 2007 Nov 1;6(21):2628-32. doi: 10.4161/cc.6.21.4930. Epub 2007 Aug 22. Cell Cycle. 2007. PMID: 17957138 Review.

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