Heck SD - Search Results

1

Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.

Zhang L, Villalobos A, Beck EM, Bocan T, Chappie TA, Chen L, Grimwood S, Heck SD, Helal CJ, Hou X, Humphrey JM, Lu J, Skaddan MB, McCarthy TJ, Verhoest PR, Wager TT, Zasadny K. Zhang L, et al. Among authors: heck sd. J Med Chem. 2013 Jun 13;56(11):4568-79. doi: 10.1021/jm400312y. Epub 2013 May 28. J Med Chem. 2013. PMID: 23651455

2

Biaryl piperidines as potent and selective delta opioid receptor ligands.

Liras S, McHardy SF, Allen MP, Segelstein BE, Heck SD, Bryce DK, Schmidt AW, Vanase-Frawley M, Callegari E, McLean S. Liras S, et al. Among authors: heck sd. Bioorg Med Chem Lett. 2010 Jan 15;20(2):503-7. doi: 10.1016/j.bmcl.2009.11.113. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20015649

3

A new class of selective and potent inhibitors of neuronal nitric oxide synthase.

Lowe JA 3rd, Qian W, Volkmann RA, Heck S, Nowakowski J, Nelson R, Nolan C, Liston D, Ward K, Zorn S, Johnson C, Vanase M, Faraci WS, Verdries KA, Baxter J, Doran S, Sanders M, Ashton M, Whittle P, Stefaniak M. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2569-72. doi: 10.1016/s0960-894x(99)00432-1. Bioorg Med Chem Lett. 1999. PMID: 10498210

4

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.

Nason DM, Heck SD, Bodenstein MS, Lowe JA 3rd, Nelson RB, Liston DR, Nolan CE, Lanyon LF, Ward KM, Volkmann RA. Nason DM, et al. Among authors: heck sd. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4511-4. doi: 10.1016/j.bmcl.2004.06.043. Bioorg Med Chem Lett. 2004. PMID: 15357982

5

Biosynthesis of D-amino acid-containing peptides: exploring the role of peptide isomerases.

Volkmann RA, Heck SD. Volkmann RA, et al. Among authors: heck sd. EXS. 1998;85:87-105. doi: 10.1007/978-3-0348-8837-0_6. EXS. 1998. PMID: 9949870 Review.

6

Posttranslational amino acid epimerization: enzyme-catalyzed isomerization of amino acid residues in peptide chains.

Heck SD, Faraci WS, Kelbaugh PR, Saccomano NA, Thadeio PF, Volkmann RA. Heck SD, et al. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4036-9. doi: 10.1073/pnas.93.9.4036. Proc Natl Acad Sci U S A. 1996. PMID: 8633012 Free PMC article.

7

Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3.

Sutton KG, Siok C, Stea A, Zamponi GW, Heck SD, Volkmann RA, Ahlijanian MK, Snutch TP. Sutton KG, et al. Among authors: heck sd. Mol Pharmacol. 1998 Aug;54(2):407-18. doi: 10.1124/mol.54.2.407. Mol Pharmacol. 1998. PMID: 9687583

8

Project-focused activity and knowledge tracker: a unified data analysis, collaboration, and workflow tool for medicinal chemistry project teams.

Brodney MD, Brosius AD, Gregory T, Heck SD, Klug-McLeod JL, Poss CS. Brodney MD, et al. Among authors: heck sd. J Chem Inf Model. 2009 Dec;49(12):2639-49. doi: 10.1021/ci9002443. J Chem Inf Model. 2009. PMID: 19899777

9

Functional consequences of posttranslational isomerization of Ser46 in a calcium channel toxin.

Heck SD, Siok CJ, Krapcho KJ, Kelbaugh PR, Thadeio PF, Welch MJ, Williams RD, Ganong AH, Kelly ME, Lanzetti AJ, et al. Heck SD, et al. Science. 1994 Nov 11;266(5187):1065-8. doi: 10.1126/science.7973665. Science. 1994. PMID: 7973665

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