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Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Eng H, Sharma R, McDonald TS, Edmonds DJ, Fortin JP, Li X, Stevens BD, Griffith DA, Limberakis C, Nolte WM, Price DA, Jackson M, Kalgutkar AS. Eng H, et al. Among authors: nolte wm. Drug Metab Dispos. 2013 Aug;41(8):1470-9. doi: 10.1124/dmd.113.052183. Epub 2013 May 7. Drug Metab Dispos. 2013. PMID: 23653442
Peptidase substrates via global peptide profiling.
Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Tagore DM, et al. Among authors: nolte wm. Nat Chem Biol. 2009 Jan;5(1):23-5. doi: 10.1038/nchembio.126. Epub 2008 Nov 16. Nat Chem Biol. 2009. PMID: 19011639 Free PMC article.
Peptidomics of the prolyl peptidases.
Lone AM, Nolte WM, Tinoco AD, Saghatelian A. Lone AM, et al. Among authors: nolte wm. AAPS J. 2010 Dec;12(4):483-91. doi: 10.1208/s12248-010-9208-y. Epub 2010 Jun 16. AAPS J. 2010. PMID: 20552307 Free PMC article. Review.
Autophagy and the immune system.
Kuballa P, Nolte WM, Castoreno AB, Xavier RJ. Kuballa P, et al. Among authors: nolte wm. Annu Rev Immunol. 2012;30:611-46. doi: 10.1146/annurev-immunol-020711-074948. Annu Rev Immunol. 2012. PMID: 22449030 Review.