Haq I - Search Results

1

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Haq I, Irving JA, Faull SV, Dickens JA, Ordóñez A, Belorgey D, Gooptu B, Lomas DA. Haq I, et al. Biosci Rep. 2013 Jun 25;33(3):e00046. doi: 10.1042/BSR20130038. Biosci Rep. 2013. PMID: 23659468 Free PMC article.

2

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.

Irving JA, Haq I, Dickens JA, Faull SV, Lomas DA. Irving JA, et al. Among authors: haq i. Biochem J. 2014 May 15;460(1):103-15. doi: 10.1042/BJ20131650. Biochem J. 2014. PMID: 24552432 Free PMC article.

3

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.

van 't Wout EF, Dickens JA, van Schadewijk A, Haq I, Kwok HF, Ordóñez A, Murphy G, Stolk J, Lomas DA, Hiemstra PS, Marciniak SJ. van 't Wout EF, et al. Among authors: haq i. Hum Mol Genet. 2014 Feb 15;23(4):929-41. doi: 10.1093/hmg/ddt487. Epub 2013 Oct 4. Hum Mol Genet. 2014. PMID: 24097797 Free PMC article.

4

Circulating polymers in α1-antitrypsin deficiency.

Tan L, Dickens JA, Demeo DL, Miranda E, Perez J, Rashid ST, Day J, Ordoñez A, Marciniak SJ, Haq I, Barker AF, Campbell EJ, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Rouhani FN, Brantly M, Lomas DA. Tan L, et al. Among authors: haq i. Eur Respir J. 2014 May;43(5):1501-4. doi: 10.1183/09031936.00111213. Epub 2014 Mar 6. Eur Respir J. 2014. PMID: 24603821 Free article. No abstract available.

5

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.

Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA. Tan L, et al. Among authors: haq i. Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13. Int J Biochem Cell Biol. 2015. PMID: 25462157 Free PMC article.

6

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.

Ordóñez A, Pérez J, Tan L, Dickens JA, Motamedi-Shad N, Irving JA, Haq I, Ekeowa U, Marciniak SJ, Miranda E, Lomas DA. Ordóñez A, et al. Among authors: haq i. FASEB J. 2015 Jun;29(6):2667-78. doi: 10.1096/fj.14-267351. Epub 2015 Mar 10. FASEB J. 2015. PMID: 25757566 Free PMC article.

7

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.

Haq I, Irving JA, Saleh AD, Dron L, Regan-Mochrie GL, Motamedi-Shad N, Hurst JR, Gooptu B, Lomas DA. Haq I, et al. Am J Respir Cell Mol Biol. 2016 Jan;54(1):71-80. doi: 10.1165/rcmb.2015-0154OC. Am J Respir Cell Mol Biol. 2016. PMID: 26091018 Free PMC article.

8

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.

Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA. Motamedi-Shad N, et al. Among authors: haq i. Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12. Biochem J. 2016. PMID: 27407165 Free PMC article.

9

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.

Miranda E, Ferrarotti I, Berardelli R, Laffranchi M, Cerea M, Gangemi F, Haq I, Ottaviani S, Lomas DA, Irving JA, Fra A. Miranda E, et al. Among authors: haq i. FEBS J. 2017 Jul;284(13):2110-2126. doi: 10.1111/febs.14111. Epub 2017 Jun 8. FEBS J. 2017. PMID: 28504839 Free PMC article.

10

Electrophoresis- and FRET-Based Measures of Serpin Polymerization.

Faull SV, Brown AE, Haq I, Irving JA. Faull SV, et al. Among authors: haq i. Methods Mol Biol. 2017;1639:235-248. doi: 10.1007/978-1-4939-7163-3_24. Methods Mol Biol. 2017. PMID: 28752464

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