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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
Gaj T, Gersbach CA, Barbas CF 3rd. Gaj T, et al. Among authors: gersbach ca. Trends Biotechnol. 2013 Jul;31(7):397-405. doi: 10.1016/j.tibtech.2013.04.004. Epub 2013 May 9. Trends Biotechnol. 2013. PMID: 23664777 Free PMC article. Review.
Multicenter integrated analysis of noncoding CRISPRi screens.
Yao D, Tycko J, Oh JW, Bounds LR, Gosai SJ, Lataniotis L, Mackay-Smith A, Doughty BR, Gabdank I, Schmidt H, Guerrero-Altamirano T, Siklenka K, Guo K, White AD, Youngworth I, Andreeva K, Ren X, Barrera A, Luo Y, Yardımcı GG, Tewhey R, Kundaje A, Greenleaf WJ, Sabeti PC, Leslie C, Pritykin Y, Moore JE, Beer MA, Gersbach CA, Reddy TE, Shen Y, Engreitz JM, Bassik MC, Reilly SK. Yao D, et al. Among authors: gersbach ca. Nat Methods. 2024 Apr;21(4):723-734. doi: 10.1038/s41592-024-02216-7. Epub 2024 Mar 19. Nat Methods. 2024. PMID: 38504114 Free PMC article.
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Yan R, et al. Among authors: gersbach ca. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. Cell Stem Cell. 2023. PMID: 36516837 Free PMC article.
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens.
McCutcheon SR, Swartz AM, Brown MC, Barrera A, McRoberts Amador C, Siklenka K, Humayun L, Ter Weele MA, Isaacs JM, Reddy TE, Allen AS, Nair SK, Antonia SJ, Gersbach CA. McCutcheon SR, et al. Among authors: gersbach ca. Nat Genet. 2023 Dec;55(12):2211-2223. doi: 10.1038/s41588-023-01554-0. Epub 2023 Nov 9. Nat Genet. 2023. PMID: 37945901 Free PMC article.
Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles.
Fletcher RB, Stokes LD, Kelly IB 3rd, Henderson KM, Vallecillo-Viejo IC, Colazo JM, Wong BV, Yu F, d'Arcy R, Struthers MN, Evans BC, Ayers J, Castanon M, Weirich MJ, Reilly SK, Patel SS, Ivanova YI, Silvera Batista CA, Weiss SM, Gersbach CA, Brunger JM, Duvall CL. Fletcher RB, et al. Among authors: gersbach ca. ACS Nano. 2023 Sep 12;17(17):16412-16431. doi: 10.1021/acsnano.2c12261. Epub 2023 Aug 15. ACS Nano. 2023. PMID: 37582231 Free PMC article.
PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system.
Lee JH, Shores KL, Breithaupt JJ, Lee CS, Fodera DM, Kwon JB, Ettyreddy AR, Myers KM, Evison BJ, Suchowerska AK, Gersbach CA, Leong KW, Truskey GA. Lee JH, et al. Among authors: gersbach ca. APL Bioeng. 2023 Oct 16;7(4):046103. doi: 10.1063/5.0167440. eCollection 2023 Dec. APL Bioeng. 2023. PMID: 37854060 Free PMC article.
Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function.
McCutcheon SR, Swartz AM, Brown MC, Barrera A, Amador CM, Siklenka K, Humayun L, Isaacs JM, Reddy TE, Nair S, Antonia S, Gersbach CA. McCutcheon SR, et al. Among authors: gersbach ca. bioRxiv [Preprint]. 2023 May 1:2023.05.01.538906. doi: 10.1101/2023.05.01.538906. bioRxiv. 2023. Update in: Nat Genet. 2023 Dec;55(12):2211-2223. doi: 10.1038/s41588-023-01554-0 PMID: 37205457 Free PMC article. Updated. Preprint.
Synthesis of programmable integrases.
Gordley RM, Gersbach CA, Barbas CF 3rd. Gordley RM, et al. Among authors: gersbach ca. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5053-8. doi: 10.1073/pnas.0812502106. Epub 2009 Mar 12. Proc Natl Acad Sci U S A. 2009. PMID: 19282480 Free PMC article.
138 results