Smith J - Search Results

1

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.

Liang J, van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair W, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liu Y, Lyssikatos J, Mantik P, Menghrajani K, Murray J, Peng I, Sambrone A, Shia S, Shin Y, Smith J, Sohn S, Tsui V, Ultsch M, Wu LC, Xiao Y, Yang W, Young J, Zhang B, Zhu BY, Magnuson S. Liang J, et al. Among authors: smith j. J Med Chem. 2013 Jun 13;56(11):4521-36. doi: 10.1021/jm400266t. Epub 2013 May 29. J Med Chem. 2013. PMID: 23668484

2

Lead identification of novel and selective TYK2 inhibitors.

Liang J, Tsui V, Van Abbema A, Bao L, Barrett K, Beresini M, Berezhkovskiy L, Blair WS, Chang C, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liimatta M, Mantik P, Menghrajani K, Murray J, Sambrone A, Xiao Y, Shia S, Shin Y, Smith J, Sohn S, Stanley M, Ultsch M, Zhang B, Wu LC, Magnuson S. Liang J, et al. Among authors: smith j. Eur J Med Chem. 2013 Sep;67:175-87. doi: 10.1016/j.ejmech.2013.03.070. Epub 2013 May 14. Eur J Med Chem. 2013. PMID: 23867602

3

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

Liang J, Van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair WS, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Goodacre S, Ghilardi N, MacLeod C, Johnson A, Bir Kohli P, Lai Y, Lin Z, Mantik P, Menghrajani K, Nguyen H, Peng I, Sambrone A, Shia S, Smith J, Sohn S, Tsui V, Ultsch M, Williams K, Wu LC, Yang W, Zhang B, Magnuson S. Liang J, et al. Among authors: smith j. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376. doi: 10.1016/j.bmcl.2017.08.022. Epub 2017 Aug 12. Bioorg Med Chem Lett. 2017. PMID: 28830649

4

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Carling RW, Leeson PD, Moore KW, Smith JD, Moyes CR, Mawer IM, Thomas S, Chan T, Baker R, Foster AC, et al. Carling RW, et al. Among authors: smith jd. J Med Chem. 1993 Oct 29;36(22):3397-408. doi: 10.1021/jm00074a021. J Med Chem. 1993. PMID: 8230130

5

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

Leeson PD, Carling RW, Moore KW, Moseley AM, Smith JD, Stevenson G, Chan T, Baker R, Foster AC, Grimwood S, et al. Leeson PD, et al. Among authors: smith jd. J Med Chem. 1992 May 29;35(11):1954-68. doi: 10.1021/jm00089a004. J Med Chem. 1992. PMID: 1534584

6

Identification and exploitation of the sigma-opiate pharmacophore.

Glennon RA, Smith JD, Ismaiel AM, el-Ashmawy M, Battaglia G, Fischer JB. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1991 Mar;34(3):1094-8. doi: 10.1021/jm00107a033. J Med Chem. 1991. PMID: 1848295

7

N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?

Glennon RA, Naiman NA, Pierson ME, Smith JD, Ismaiel AM, Titeler M, Lyon RA. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1989 Aug;32(8):1921-6. doi: 10.1021/jm00128a039. J Med Chem. 1989. PMID: 2754715

8

Mesoionic purinone analogues as inhibitors of cyclic-AMP phosphodiesterase: a comparison of several ring systems.

Rogers ME, Glennon RA, Smith JD, Boots MR, Nanavati N, Maconaughey E, Aub D, Thomas S, Bass RG, Mbagwu G. Rogers ME, et al. Among authors: smith jd. J Med Chem. 1981 Nov;24(11):1284-7. doi: 10.1021/jm00143a004. J Med Chem. 1981. PMID: 6273558

9

Mesoionic xanthine analogues: phosphodiesterase inhibitory and hypotensive activity.

Glennon RA, Rogers ME, Smith JD, El-Said MK, Egle JL. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1981 Jun;24(6):658-61. doi: 10.1021/jm00138a002. J Med Chem. 1981. PMID: 6265635

10

Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.

Glennon RA, Ismaiel AM, Smith JD, Yousif M, el-Ashmawy M, Herndon JL, Fischer JB, Howie KJ, Server AC. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1991 Jun;34(6):1855-9. doi: 10.1021/jm00110a015. J Med Chem. 1991. PMID: 1648139

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