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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: tambar uk. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716694 Free PMC article.
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Scheuermann TH, et al. Among authors: tambar uk. Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24. Nat Chem Biol. 2013. PMID: 23434853 Free PMC article.
A trimethoprim derivative impedes antibiotic resistance evolution.
Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E. Manna MS, et al. Nat Commun. 2021 May 19;12(1):2949. doi: 10.1038/s41467-021-23191-z. Nat Commun. 2021. PMID: 34011959 Free PMC article.
Metabolic inflexibility promotes mitochondrial health during liver regeneration.
Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SSK, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P. Wang X, et al. Among authors: tambar uk. Science. 2024 Jun 14;384(6701):eadj4301. doi: 10.1126/science.adj4301. Epub 2024 Jun 14. Science. 2024. PMID: 38870309 Free PMC article.
Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Rogers JL, et al. Among authors: tambar uk. J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23363003 Free PMC article.
56 results