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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Possemato R, et al. Among authors: kalaany ny. Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. Nature. 2011. PMID: 21760589 Free PMC article.
Autophagy is required for glucose homeostasis and lung tumor maintenance.
Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Karsli-Uzunbas G, et al. Among authors: kalaany ny. Cancer Discov. 2014 Aug;4(8):914-27. doi: 10.1158/2159-8290.CD-14-0363. Epub 2014 May 29. Cancer Discov. 2014. PMID: 24875857 Free PMC article.
Starved epithelial cells uptake extracellular matrix for survival.
Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Muranen T, et al. Among authors: kalaany ny. Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989. Nat Commun. 2017. PMID: 28071763 Free PMC article.
Critical role for arginase 2 in obesity-associated pancreatic cancer.
Zaytouni T, Tsai PY, Hitchcock DS, DuBois CD, Freinkman E, Lin L, Morales-Oyarvide V, Lenehan PJ, Wolpin BM, Mino-Kenudson M, Torres EM, Stylopoulos N, Clish CB, Kalaany NY. Zaytouni T, et al. Among authors: kalaany ny. Nat Commun. 2017 Aug 14;8(1):242. doi: 10.1038/s41467-017-00331-y. Nat Commun. 2017. PMID: 28808255 Free PMC article.
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Xu H, et al. Among authors: kalaany ny. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610318 Free PMC article.
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.
Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY. Tsai PY, et al. Among authors: kalaany ny. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2003014118. doi: 10.1073/pnas.2003014118. Proc Natl Acad Sci U S A. 2021. PMID: 33653947 Free PMC article.
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