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Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. Zhang J, et al. Among authors: takahashi s. J Biol Chem. 2013 Jul 12;288(28):20692-701. doi: 10.1074/jbc.M113.485730. Epub 2013 May 29. J Biol Chem. 2013. PMID: 23720771 Free PMC article.
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T. Anai M, et al. Among authors: takahashi s. J Biol Chem. 2005 May 6;280(18):18525-35. doi: 10.1074/jbc.M500586200. Epub 2005 Mar 7. J Biol Chem. 2005. PMID: 15753085 Free article.
Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.
Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: takahashi s. Endocrinology. 2008 Jul;149(7):3729-42. doi: 10.1210/en.2007-1443. Epub 2008 Apr 10. Endocrinology. 2008. PMID: 18403485
Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway.
Sasaki-Suzuki N, Arai K, Ogata T, Kasahara K, Sakoda H, Chida K, Asano T, Pessin JE, Hakuno F, Takahashi S. Sasaki-Suzuki N, et al. Among authors: takahashi s. J Biol Chem. 2009 Mar 6;284(10):6061-70. doi: 10.1074/jbc.M808282200. Epub 2009 Jan 2. J Biol Chem. 2009. PMID: 19122000 Free PMC article.
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.
Shibata M, Hakuno F, Yamanaka D, Okajima H, Fukushima T, Hasegawa T, Ogata T, Toyoshima Y, Chida K, Kimura K, Sakoda H, Takenaka A, Asano T, Takahashi S. Shibata M, et al. Among authors: takahashi s. J Biol Chem. 2010 Jul 2;285(27):20915-25. doi: 10.1074/jbc.M110.126482. Epub 2010 Apr 29. J Biol Chem. 2010. PMID: 20430890 Free PMC article.
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. J Biol Chem. 2010 Oct 22;285(43):33018-33027. doi: 10.1074/jbc.M110.137836. Epub 2010 Jul 30. J Biol Chem. 2010. PMID: 20675384 Free PMC article.
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