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Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST. Figueiredo CP, et al. Among authors: saraiva lm. J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013. J Neurosci. 2013. PMID: 23739959 Free PMC article.
Amyloid-β oligomers induce differential gene expression in adult human brain slices.
Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Mota LD, Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De Felice FG, Ferreira ST. Sebollela A, et al. Among authors: saraiva lm. J Biol Chem. 2012 Mar 2;287(10):7436-45. doi: 10.1074/jbc.M111.298471. Epub 2012 Jan 10. J Biol Chem. 2012. PMID: 22235132 Free PMC article. Clinical Trial.
Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.
de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST. de Godoy MA, et al. Among authors: saraiva lm. J Biol Chem. 2018 Feb 9;293(6):1957-1975. doi: 10.1074/jbc.M117.807180. Epub 2017 Dec 28. J Biol Chem. 2018. PMID: 29284679 Free PMC article.
Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.
Bodart-Santos V, de Carvalho LRP, de Godoy MA, Batista AF, Saraiva LM, Lima LG, Abreu CA, De Felice FG, Galina A, Mendez-Otero R, Ferreira ST. Bodart-Santos V, et al. Among authors: saraiva lm. Stem Cell Res Ther. 2019 Nov 20;10(1):332. doi: 10.1186/s13287-019-1432-5. Stem Cell Res Ther. 2019. PMID: 31747944 Free PMC article.
127 results