Androphy EJ - Search Results

1

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds.

Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Cherry JJ, et al. Among authors: androphy ej. EMBO Mol Med. 2013 Jul;5(7):1103-18. doi: 10.1002/emmm.201202305. Epub 2013 Jun 5. EMBO Mol Med. 2013. PMID: 23740718 Free PMC article.

2

Differential regulation of the SMN2 gene by individual HDAC proteins.

Evans MC, Cherry JJ, Androphy EJ. Evans MC, et al. Among authors: androphy ej. Biochem Biophys Res Commun. 2011 Oct 14;414(1):25-30. doi: 10.1016/j.bbrc.2011.09.011. Epub 2011 Sep 6. Biochem Biophys Res Commun. 2011. PMID: 21925145 Free PMC article.

3

Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay.

Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ. Cherry JJ, et al. Among authors: androphy ej. J Biomol Screen. 2012 Apr;17(4):481-95. doi: 10.1177/1087057111431605. Epub 2012 Jan 10. J Biomol Screen. 2012. PMID: 22233647 Free PMC article.

4

Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy.

Rietz A, Hodgetts KJ, Lusic H, Quist KM, Osman EY, Lorson CL, Androphy EJ. Rietz A, et al. Among authors: androphy ej. Life Sci Alliance. 2020 Nov 24;4(1):e202000889. doi: 10.26508/lsa.202000889. Print 2021 Jan. Life Sci Alliance. 2020. PMID: 33234679 Free PMC article.

5

Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.

Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Rietz A, et al. Among authors: androphy ej. J Med Chem. 2017 Jun 8;60(11):4594-4610. doi: 10.1021/acs.jmedchem.6b01885. Epub 2017 May 19. J Med Chem. 2017. PMID: 28481536 Free PMC article.

6

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy.

Lorson CL, Hahnen E, Androphy EJ, Wirth B. Lorson CL, et al. Among authors: androphy ej. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6307-11. doi: 10.1073/pnas.96.11.6307. Proc Natl Acad Sci U S A. 1999. PMID: 10339583 Free PMC article.

7

An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN.

Lorson CL, Androphy EJ. Lorson CL, et al. Among authors: androphy ej. Hum Mol Genet. 2000 Jan 22;9(2):259-65. doi: 10.1093/hmg/9.2.259. Hum Mol Genet. 2000. PMID: 10607836

8

Intraperitoneal delivery of a novel drug-like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy.

Osman EY, Rietz A, Kline RA, Cherry JJ, Hodgetts KJ, Lorson CL, Androphy EJ. Osman EY, et al. Among authors: androphy ej. Sci Rep. 2019 Feb 7;9(1):1633. doi: 10.1038/s41598-018-38208-9. Sci Rep. 2019. PMID: 30733501 Free PMC article.

9

A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy.

Young PJ, Day PM, Zhou J, Androphy EJ, Morris GE, Lorson CL. Young PJ, et al. Among authors: androphy ej. J Biol Chem. 2002 Jan 25;277(4):2852-9. doi: 10.1074/jbc.M108769200. Epub 2001 Nov 9. J Biol Chem. 2002. PMID: 11704667 Free article.

10

The COPI vesicle complex binds and moves with survival motor neuron within axons.

Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. Peter CJ, et al. Among authors: androphy ej. Hum Mol Genet. 2011 May 1;20(9):1701-11. doi: 10.1093/hmg/ddr046. Epub 2011 Feb 7. Hum Mol Genet. 2011. PMID: 21300694 Free PMC article.

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