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A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.
Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X. Liu W, et al. Among authors: ke y. Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10. Circ Heart Fail. 2013. PMID: 23753531 Free PMC article.
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X. Liu W, et al. Among authors: ke y. Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14. Circulation. 2011. PMID: 22082674 Free PMC article.
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Egom EE, Mohamed TM, Mamas MA, Shi Y, Liu W, Chirico D, Stringer SE, Ke Y, Shaheen M, Wang T, Chacko S, Wang X, Solaro RJ, Fath-Ordoubadi F, Cartwright EJ, Lei M. Egom EE, et al. Among authors: ke y. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1487-95. doi: 10.1152/ajpheart.01003.2010. Epub 2011 Jun 24. Am J Physiol Heart Circ Physiol. 2011. PMID: 21705677 Free PMC article.
Pak1 is required to maintain ventricular Ca²⁺ homeostasis and electrophysiological stability through SERCA2a regulation in mice.
Wang Y, Tsui H, Ke Y, Shi Y, Li Y, Davies L, Cartwright EJ, Venetucci L, Zhang H, Terrar DA, Huang CL, Solaro RJ, Wang X, Lei M. Wang Y, et al. Among authors: ke y. Circ Arrhythm Electrophysiol. 2014 Oct;7(5):938-48. doi: 10.1161/CIRCEP.113.001198. Epub 2014 Sep 12. Circ Arrhythm Electrophysiol. 2014. PMID: 25217043 Free PMC article.
Novel roles of PAK1 in the heart.
Ke Y, Lei M, Wang X, Solaro RJ. Ke Y, et al. Cell Logist. 2012 Apr 1;2(2):89-94. doi: 10.4161/cl.21497. Cell Logist. 2012. PMID: 23162741 Free PMC article.
3,287 results