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A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. Thorsell A, et al. J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013. J Neurosci. 2013. PMID: 23761908 Free PMC article.
Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation.
Cippitelli A, Damadzic R, Frankola K, Goldstein A, Thorsell A, Singley E, Eskay RL, Heilig M. Cippitelli A, et al. Among authors: thorsell a. Biol Psychiatry. 2010 May 1;67(9):823-30. doi: 10.1016/j.biopsych.2009.12.018. Epub 2010 Feb 4. Biol Psychiatry. 2010. PMID: 20132926
Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats.
Cippitelli A, Damadzic R, Singley E, Thorsell A, Ciccocioppo R, Eskay RL, Heilig M. Cippitelli A, et al. Among authors: thorsell a. Pharmacol Biochem Behav. 2012 Jan;100(3):522-9. doi: 10.1016/j.pbb.2011.10.016. Epub 2011 Oct 20. Pharmacol Biochem Behav. 2012. PMID: 22036774 Free PMC article.
153 results