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Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement.
Sethu S, Govindappa K, Quinn P, Wadhwa M, Stebbings R, Boggild M, Naisbitt D, Kimber I, Pirmohamed M, Park K, Sathish J. Sethu S, et al. Among authors: kimber i. Clin Immunol. 2013 Aug;148(2):177-85. doi: 10.1016/j.clim.2013.05.008. Epub 2013 May 22. Clin Immunol. 2013. PMID: 23770627 Free PMC article.
Challenges and approaches for the development of safer immunomodulatory biologics.
Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CE, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, Van Der Laan JW, Weaver RJ, Park BK. Sathish JG, et al. Among authors: kimber i. Nat Rev Drug Discov. 2013 Apr;12(4):306-24. doi: 10.1038/nrd3974. Nat Rev Drug Discov. 2013. PMID: 23535934 Free PMC article. Review.
597 results