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22 results

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Page 1
Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.
Liu A, Lute J, Gu H, Wang B, Trouba KJ, Arnold ME, Aubry AF, Wang J. Liu A, et al. Among authors: trouba kj. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:29-40. doi: 10.1016/j.jchromb.2015.07.006. Epub 2015 Jul 13. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 26209768
Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.
Zhao Y, Liu G, Angeles A, Hamuro LL, Trouba KJ, Wang B, Pillutla RC, DeSilva BS, Arnold ME, Shen JX. Zhao Y, et al. Among authors: trouba kj. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:81-7. doi: 10.1016/j.jchromb.2015.02.007. Epub 2015 Feb 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25756208
In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity.
Li W, Trouba KJ, Ma L, Kwagh J, Storck C, Zhu Y, Flint O, Humphreys WG, Wang J, Liu A, Wang B, Graziano MJ, Davies MH, Sanderson TP. Li W, et al. Among authors: trouba kj. Int J Toxicol. 2017 Jan-Feb;36(1):35-49. doi: 10.1177/1091581816683642. Epub 2017 Jan 5. Int J Toxicol. 2017. PMID: 28056568
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: trouba k. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017).
Adams K, Clemons D, Impelluso LC, Lee D, Maguire S, Myers A, Petursson C, Schulingkamp R, Trouba K, Wright M. Adams K, et al. Among authors: trouba k. Toxicol Pathol. 2019 Jul;47(5):649-655. doi: 10.1177/0192623319857976. Epub 2019 Jul 7. Toxicol Pathol. 2019. PMID: 31280699
Discovery and pharmacological characterization of cetrelimab (JNJ-63723283), an anti-programmed cell death protein-1 (PD-1) antibody, in human cancer models.
DeAngelis N, Ferrante C, Powers G, Sendecki J, Mattson B, Pizutti D, Packman K, Wang W, Trouba K, Nanjunda R, Wheeler J, Brittingham R, Wu SJ, Luo J, Lorenzi MV, Verona RI. DeAngelis N, et al. Among authors: trouba k. Cancer Chemother Pharmacol. 2022 Apr;89(4):515-527. doi: 10.1007/s00280-022-04415-5. Epub 2022 Mar 17. Cancer Chemother Pharmacol. 2022. PMID: 35298699 Free PMC article.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Prior H, Andrews L, Cauvin A, Chien H, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Reid K, Schutte K, Sewell F, Trouba K, Ulrich P, van Aerts L, van Meer P, Weir L. Prior H, et al. Among authors: trouba k. Regul Toxicol Pharmacol. 2023 Feb;138:105339. doi: 10.1016/j.yrtph.2023.105339. Epub 2023 Jan 14. Regul Toxicol Pharmacol. 2023. PMID: 36649820 Free article. Review.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Chien HT, Prior H, Andrews L, van Aerts L, Cauvin A, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Schutte K, Sewell F, Trouba K, Ulrich P, Weir L, van Meer P. Chien HT, et al. Among authors: trouba k. Regul Toxicol Pharmacol. 2023 Feb;138:105329. doi: 10.1016/j.yrtph.2022.105329. Epub 2022 Dec 30. Regul Toxicol Pharmacol. 2023. PMID: 36592682 Free article.
22 results