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Page 1
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. Wilson R, et al. Among authors: barnes sw. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16. Nat Chem Biol. 2013. PMID: 23770708 Free PMC article.
Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, Larsen MH, Jacobs WR Jr. Waters WR, et al. Among authors: barnes sw. Vaccine. 2009 Feb 18;27(8):1201-9. doi: 10.1016/j.vaccine.2008.12.018. Epub 2009 Jan 9. Vaccine. 2009. PMID: 19135497 Free PMC article.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T. Pethe K, et al. Among authors: barnes sw. Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060. Nat Commun. 2010. PMID: 20975714 Free PMC article.
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE 3rd, Boshoff HI. Tahlan K, et al. Among authors: barnes sw. Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809. doi: 10.1128/AAC.05708-11. Epub 2012 Jan 17. Antimicrob Agents Chemother. 2012. PMID: 22252828 Free PMC article.
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnsson K, Mikusova K, Besra GS, Fütterer K, Robbins SH, Barnes SW, Walker JR, Jacobs WR Jr, Schultz PG. Wang F, et al. Among authors: barnes sw. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. doi: 10.1073/pnas.1309171110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776209 Free PMC article.
Direct inhibitors of InhA are active against Mycobacterium tuberculosis.
Manjunatha UH, S Rao SP, Kondreddi RR, Noble CG, Camacho LR, Tan BH, Ng SH, Ng PS, Ma NL, Lakshminarayana SB, Herve M, Barnes SW, Yu W, Kuhen K, Blasco F, Beer D, Walker JR, Tonge PJ, Glynne R, Smith PW, Diagana TT. Manjunatha UH, et al. Among authors: barnes sw. Sci Transl Med. 2015 Jan 7;7(269):269ra3. doi: 10.1126/scitranslmed.3010597. Sci Transl Med. 2015. PMID: 25568071 Free PMC article.
Defects in Efflux (oprM), β-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61.
Shen X, Johnson NV, Kreamer NNK, Barnes SW, Walker JR, Woods AL, Six DA, Dean CR. Shen X, et al. Among authors: barnes sw. Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00784-19. doi: 10.1128/AAC.00784-19. Print 2019 Jul. Antimicrob Agents Chemother. 2019. PMID: 31036686 Free PMC article.
Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Jones AK, Caughlan RE, Woods AL, Uehara K, Xie L, Barnes SW, Walker JR, Thompson KV, Ranjitkar S, Lee PS, Dean CR. Jones AK, et al. Among authors: barnes sw. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01490-19. doi: 10.1128/AAC.01490-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31658970 Free PMC article.
33 results