Kremer L - Search Results

1

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. Wilson R, et al. Among authors: kremer l. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16. Nat Chem Biol. 2013. PMID: 23770708 Free PMC article.

2

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.

Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR Jr, Brennan PJ, Minnikin DE, Besra GS. Kremer L, et al. J Biol Chem. 2000 Jun 2;275(22):16857-64. doi: 10.1074/jbc.M000569200. J Biol Chem. 2000. PMID: 10747933 Free article.

3

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.

Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR Jr. Larsen MH, et al. Among authors: kremer l. Mol Microbiol. 2002 Oct;46(2):453-66. doi: 10.1046/j.1365-2958.2002.03162.x. Mol Microbiol. 2002. PMID: 12406221 Free article.

4

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR Jr, Besra GS. Kremer L, et al. J Biol Chem. 2003 Jun 6;278(23):20547-54. doi: 10.1074/jbc.M302435200. Epub 2003 Mar 24. J Biol Chem. 2003. PMID: 12654922 Free article.

5

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

Vilchèze C, Weisbrod TR, Chen B, Kremer L, Hazbón MH, Wang F, Alland D, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: kremer l. Antimicrob Agents Chemother. 2005 Feb;49(2):708-20. doi: 10.1128/AAC.49.2.708-720.2005. Antimicrob Agents Chemother. 2005. PMID: 15673755 Free PMC article.

6

Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

Bhatt A, Kremer L, Dai AZ, Sacchettini JC, Jacobs WR Jr. Bhatt A, et al. Among authors: kremer l. J Bacteriol. 2005 Nov;187(22):7596-606. doi: 10.1128/JB.187.22.7596-7606.2005. J Bacteriol. 2005. PMID: 16267284 Free PMC article.

7

GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.

Ojha A, Anand M, Bhatt A, Kremer L, Jacobs WR Jr, Hatfull GF. Ojha A, et al. Among authors: kremer l. Cell. 2005 Dec 2;123(5):861-73. doi: 10.1016/j.cell.2005.09.012. Cell. 2005. PMID: 16325580 Free article.

8

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.

Morbidoni HR, Vilchèze C, Kremer L, Bittman R, Sacchettini JC, Jacobs WR Jr. Morbidoni HR, et al. Among authors: kremer l. Chem Biol. 2006 Mar;13(3):297-307. doi: 10.1016/j.chembiol.2006.01.005. Chem Biol. 2006. PMID: 16638535

9

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

Vilchèze C, Wang F, Arai M, Hazbón MH, Colangeli R, Kremer L, Weisbrod TR, Alland D, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: kremer l. Nat Med. 2006 Sep;12(9):1027-9. doi: 10.1038/nm1466. Epub 2006 Aug 13. Nat Med. 2006. PMID: 16906155

10

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.

Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, Jacobs WR Jr. Bhatt A, et al. Among authors: kremer l. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5157-62. doi: 10.1073/pnas.0608654104. Epub 2007 Mar 12. Proc Natl Acad Sci U S A. 2007. PMID: 17360388 Free PMC article.

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