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Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2.
Sprowl JA, Ciarimboli G, Lancaster CS, Giovinazzo H, Gibson AA, Du G, Janke LJ, Cavaletti G, Shields AF, Sparreboom A. Sprowl JA, et al. Among authors: cavaletti g. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11199-204. doi: 10.1073/pnas.1305321110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776246 Free PMC article.
A phosphotyrosine switch regulates organic cation transporters.
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. Sprowl JA, et al. Among authors: cavaletti g. Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880. Nat Commun. 2016. PMID: 26979622 Free PMC article.
OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.
Leblanc AF, Sprowl JA, Alberti P, Chiorazzi A, Arnold WD, Gibson AA, Hong KW, Pioso MS, Chen M, Huang KM, Chodisetty V, Costa O, Florea T, de Bruijn P, Mathijssen RH, Reinbolt RE, Lustberg MB, Sucheston-Campbell LE, Cavaletti G, Sparreboom A, Hu S. Leblanc AF, et al. Among authors: cavaletti g. J Clin Invest. 2018 Feb 1;128(2):816-825. doi: 10.1172/JCI96160. Epub 2018 Jan 16. J Clin Invest. 2018. PMID: 29337310 Free PMC article.
An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection.
Hucke A, Rinschen MM, Bauer OB, Sperling M, Karst U, Köppen C, Sommer K, Schröter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S, Marmiroli P, Cavaletti G, Schlatt S, Schlatter E, Pavenstädt H, Heitplatz B, Van Marck V, Sparreboom A, Barz V, Knief A, Deuster D, Zehnhoff-Dinnesen AA, Ciarimboli G. Hucke A, et al. Among authors: cavaletti g. Arch Toxicol. 2019 Oct;93(10):2835-2848. doi: 10.1007/s00204-019-02557-9. Epub 2019 Sep 6. Arch Toxicol. 2019. PMID: 31493026
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson AA, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg MB, Cavaletti G, Pabla N, Hu S, Sparreboom A. Huang KM, et al. Among authors: cavaletti g. J Clin Invest. 2020 Sep 1;130(9):4601-4606. doi: 10.1172/JCI136796. J Clin Invest. 2020. PMID: 32484793 Free PMC article.
Clinical pattern and associations of oxaliplatin acute neurotoxicity: a prospective study in 170 patients with colorectal cancer.
Argyriou AA, Cavaletti G, Briani C, Velasco R, Bruna J, Campagnolo M, Alberti P, Bergamo F, Cortinovis D, Cazzaniga M, Santos C, Papadimitriou K, Kalofonos HP. Argyriou AA, et al. Among authors: cavaletti g. Cancer. 2013 Jan 15;119(2):438-44. doi: 10.1002/cncr.27732. Epub 2012 Jul 11. Cancer. 2013. PMID: 22786764 Free article.
Chemotherapy-induced peripheral neurotoxicity.
Cavaletti G, Marmiroli P. Cavaletti G, et al. Curr Opin Neurol. 2015 Oct;28(5):500-7. doi: 10.1097/WCO.0000000000000234. Curr Opin Neurol. 2015. PMID: 26197027 Review.
418 results