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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V. Pybus BS, et al. Among authors: ohrt c. Malar J. 2013 Jun 20;12:212. doi: 10.1186/1475-2875-12-212. Malar J. 2013. PMID: 23782898 Free PMC article.
Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.
Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA. Nanayakkara NP, et al. Among authors: ohrt c. Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9. Antimicrob Agents Chemother. 2014. PMID: 24913163 Free PMC article.
Absolute bioavailability of cis-mirincamycin and trans-mirincamycin in healthy rhesus monkeys and ex vivo antimalarial activity against Plasmodium falciparum.
Khemawoot P, Saunders D, Rasameesoraj M, Melendez V, Imerbsin R, Ohrt C, Fracisco S, Teja-Isavadharm P. Khemawoot P, et al. Among authors: ohrt c. Antimicrob Agents Chemother. 2011 Dec;55(12):5881-6. doi: 10.1128/AAC.01619-10. Epub 2011 Sep 26. Antimicrob Agents Chemother. 2011. PMID: 21947400 Free PMC article.
Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).
Saunders D, Vanachayangkul P, Imerbsin R, Khemawoot P, Siripokasupkul R, Tekwani BL, Sampath A, Nanayakkara NP, Ohrt C, Lanteri C, Gettyacamin M, Teja-Isavadharm P, Walker L. Saunders D, et al. Among authors: ohrt c. Antimicrob Agents Chemother. 2014 Dec;58(12):7283-91. doi: 10.1128/AAC.02576-13. Epub 2014 Sep 29. Antimicrob Agents Chemother. 2014. PMID: 25267666 Free PMC article.
71 results