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Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. Lavieri RR, et al. Among authors: scott sa. J Med Chem. 2010 Sep 23;53(18):6706-19. doi: 10.1021/jm100814g. J Med Chem. 2010. PMID: 20735042 Free PMC article.
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.
O'Reilly MC, Scott SA, Brown KA, Oguin TH 3rd, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW. O'Reilly MC, et al. Among authors: scott sa. J Med Chem. 2013 Mar 28;56(6):2695-9. doi: 10.1021/jm301782e. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23445448 Free PMC article.
Chemical modulation of glycerolipid signaling and metabolic pathways.
Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA. Scott SA, et al. Biochim Biophys Acta. 2014 Aug;1841(8):1060-84. doi: 10.1016/j.bbalip.2014.01.009. Epub 2014 Jan 15. Biochim Biophys Acta. 2014. PMID: 24440821 Free PMC article. Review.
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. Lewis JA, et al. Among authors: scott sa. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20. doi: 10.1016/j.bmcl.2009.02.057. Epub 2009 Feb 20. Bioorg Med Chem Lett. 2009. PMID: 19268584 Free PMC article.
Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains.
O'Reilly MC, Oguin TH 3rd, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW. O'Reilly MC, et al. Among authors: scott sa. ChemMedChem. 2014 Dec;9(12):2633-7. doi: 10.1002/cmdc.201402333. Epub 2014 Sep 10. ChemMedChem. 2014. PMID: 25210004 Free PMC article.
332 results