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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. Georgiadou E, et al. Among authors: haythorne e. Diabetologia. 2020 Jul;63(7):1368-1381. doi: 10.1007/s00125-020-05148-x. Epub 2020 Apr 29. Diabetologia. 2020. PMID: 32350566 Free PMC article.
Local and regional control of calcium dynamics in the pancreatic islet.
Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I. Rutter GA, et al. Among authors: haythorne e. Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Diabetes Obes Metab. 2017. PMID: 28466490 Free article. Review.
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. Carrat GR, et al. Among authors: haythorne e. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. Mol Metab. 2020. PMID: 32416313 Free PMC article.
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.
Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ. Johnston NR, et al. Among authors: haythorne e. Cell Metab. 2016 Sep 13;24(3):389-401. doi: 10.1016/j.cmet.2016.06.020. Epub 2016 Jul 21. Cell Metab. 2016. PMID: 27452146 Free PMC article.
Chronic d-serine supplementation impairs insulin secretion.
Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S. Suwandhi L, et al. Among authors: haythorne e. Mol Metab. 2018 Oct;16:191-202. doi: 10.1016/j.molmet.2018.07.002. Epub 2018 Jul 25. Mol Metab. 2018. PMID: 30093356 Free PMC article.
18 results