Gertz M - Search Results

1

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.

Gertz M, Fischer F, Nguyen GT, Lakshminarasimhan M, Schutkowski M, Weyand M, Steegborn C. Gertz M, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. doi: 10.1073/pnas.1303628110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840057 Free PMC article.

2

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.

Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, Steegborn C. Fischer F, et al. Among authors: gertz m. PLoS One. 2012;7(9):e45098. doi: 10.1371/journal.pone.0045098. Epub 2012 Sep 19. PLoS One. 2012. PMID: 23028781 Free PMC article.

3

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C. Gertz M, et al. PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185430 Free PMC article.

4

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.

Nguyen GT, Schaefer S, Gertz M, Weyand M, Steegborn C. Nguyen GT, et al. Among authors: gertz m. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1423-32. doi: 10.1107/S0907444913015448. Epub 2013 Jul 17. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23897466

5

Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.

Nguyen GT, Gertz M, Steegborn C. Nguyen GT, et al. Among authors: gertz m. Chem Biol. 2013 Nov 21;20(11):1375-85. doi: 10.1016/j.chembiol.2013.09.019. Epub 2013 Nov 7. Chem Biol. 2013. PMID: 24211137

6

Using mitochondrial sirtuins as drug targets: disease implications and available compounds.

Gertz M, Steegborn C. Gertz M, et al. Cell Mol Life Sci. 2016 Aug;73(15):2871-96. doi: 10.1007/s00018-016-2180-7. Epub 2016 Mar 23. Cell Mol Life Sci. 2016. PMID: 27007507 Free PMC article. Review.

7

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.

Gertz M, Fischer F, Wolters D, Steegborn C. Gertz M, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5705-9. doi: 10.1073/pnas.0800691105. Epub 2008 Apr 14. Proc Natl Acad Sci U S A. 2008. PMID: 18413607 Free PMC article.

8

Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.

Gertz M, Steegborn C. Gertz M, et al. Biochim Biophys Acta. 2010 Aug;1804(8):1658-65. doi: 10.1016/j.bbapap.2009.09.011. Epub 2009 Sep 18. Biochim Biophys Acta. 2010. PMID: 19766741 Review.

9

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CF, Zerweck J, Schutkowski M, Steegborn C. Rauh D, et al. Among authors: gertz m. Nat Commun. 2013;4:2327. doi: 10.1038/ncomms3327. Nat Commun. 2013. PMID: 23995836 Free article.

10

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.

Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M. Roessler C, et al. Among authors: gertz m. Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10728-32. doi: 10.1002/anie.201402679. Epub 2014 Aug 11. Angew Chem Int Ed Engl. 2014. PMID: 25111069

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