Gangloff AR - Search Results

1

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.

Gangloff AR, Brown J, de Jong R, Dougan DR, Grimshaw CE, Hixon M, Jennings A, Kamran R, Kiryanov A, O'Connell S, Taylor E, Vu P. Gangloff AR, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4501-5. doi: 10.1016/j.bmcl.2013.06.055. Epub 2013 Jun 24. Bioorg Med Chem Lett. 2013. PMID: 23850199

2

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.

Bressi JC, de Jong R, Wu Y, Jennings AJ, Brown JW, O'Connell S, Tari LW, Skene RJ, Vu P, Navre M, Cao X, Gangloff AR. Bressi JC, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2010 May 15;20(10):3138-41. doi: 10.1016/j.bmcl.2010.03.092. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20392637

3

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

Bressi JC, Jennings AJ, Skene R, Wu Y, Melkus R, De Jong R, O'Connell S, Grimshaw CE, Navre M, Gangloff AR. Bressi JC, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. doi: 10.1016/j.bmcl.2010.03.091. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20392638

4

Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.

Keung W, Boloor A, Brown J, Kiryanov A, Gangloff A, Lawson JD, Skene R, Hoffman I, Atienza J, Kahana J, De Jong R, Farrell P, Balakrishna D, Halkowycz P. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. doi: 10.1016/j.bmcl.2016.12.024. Epub 2016 Dec 20. Bioorg Med Chem Lett. 2017. PMID: 28082036

5

Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors.

Rice KD, Gangloff AR, Kuo EY, Dener JM, Wang VR, Lum R, Newcomb WS, Havel C, Putnam D, Cregar L, Wong M, Warne RL. Rice KD, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2357-60. doi: 10.1016/s0960-894x(00)00484-4. Bioorg Med Chem Lett. 2000. PMID: 11055355

6

Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.

Rice KD, Wang VR, Gangloff AR, Kuo EY, Dener JM, Newcomb WS, Young WB, Putnam D, Cregar L, Wong M, Simpson PJ. Rice KD, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2361-6. doi: 10.1016/s0960-894x(00)00485-6. Bioorg Med Chem Lett. 2000. PMID: 11055356

7

Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.

Dener JM, Rice KD, Newcomb WS, Wang VR, Young WB, Gangloff AR, Kuo EY, Cregar L, Putnam D, Wong M. Dener JM, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1629-33. doi: 10.1016/s0960-894x(01)00254-2. Bioorg Med Chem Lett. 2001. PMID: 11425524

8

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.

Sperandio D, Gangloff AR, Litvak J, Goldsmith R, Hataye JM, Wang VR, Shelton EJ, Elrod K, Janc JW, Clark JM, Rice K, Weinheimer S, Yeung KS, Meanwell NA, Hernandez D, Staab AJ, Venables BL, Spencer JR. Sperandio D, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3129-33. doi: 10.1016/s0960-894x(02)00680-7. Bioorg Med Chem Lett. 2002. PMID: 12372517

9

Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.

Dener JM, Wang VR, Rice KD, Gangloff AR, Kuo EY, Newcomb WS, Putnam D, Wong M. Dener JM, et al. Among authors: gangloff ar. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2325-30. doi: 10.1016/s0960-894x(01)00444-9. Bioorg Med Chem Lett. 2001. PMID: 11527724

10

Tryptase inhibitors in the treatment of pulmonary diseases.

Gangloff AR. Gangloff AR. Curr Opin Investig Drugs. 2000 Sep;1(1):79-85. Curr Opin Investig Drugs. 2000. PMID: 11249600 Review. No abstract available.

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