Shahane SA - Search Results

1

Are hERG channel blockers also phospholipidosis inducers?

Sun H, Xia M, Shahane SA, Jadhav A, Austin CP, Huang R. Sun H, et al. Among authors: shahane sa. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4587-90. doi: 10.1016/j.bmcl.2013.06.034. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23856051 Free PMC article.

2

Structure based model for the prediction of phospholipidosis induction potential of small molecules.

Sun H, Shahane S, Xia M, Austin CP, Huang R. Sun H, et al. J Chem Inf Model. 2012 Jul 23;52(7):1798-805. doi: 10.1021/ci3001875. Epub 2012 Jul 5. J Chem Inf Model. 2012. PMID: 22725677 Free PMC article.

3

Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.

Sun H, Huang R, Xia M, Shahane S, Southall N, Wang Y. Sun H, et al. Mol Inform. 2017 Apr;36(4):10.1002/minf.201600126. doi: 10.1002/minf.201600126. Epub 2016 Dec 21. Mol Inform. 2017. PMID: 28000393 Free PMC article.

4

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Xia M, et al. Among authors: shahane sa. Toxicol Appl Pharmacol. 2011 May 1;252(3):250-8. doi: 10.1016/j.taap.2011.02.016. Epub 2011 Feb 26. Toxicol Appl Pharmacol. 2011. PMID: 21362439 Free PMC article.

5

Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format.

Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M. Shahane SA, et al. J Biomol Screen. 2014 Jan;19(1):66-76. doi: 10.1177/1087057113502851. Epub 2013 Sep 3. J Biomol Screen. 2014. PMID: 24003057 Free PMC article.

6

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. Titus SA, et al. Among authors: shahane sa. Anal Biochem. 2009 Nov 1;394(1):30-8. doi: 10.1016/j.ab.2009.07.003. Epub 2009 Jul 5. Anal Biochem. 2009. PMID: 19583963 Free PMC article.

7

Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.

Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Xia M, et al. Among authors: shahane sa. Cell Mol Neurobiol. 2011 Aug;31(6):901-7. doi: 10.1007/s10571-011-9689-y. Epub 2011 May 20. Cell Mol Neurobiol. 2011. PMID: 21598037 Free PMC article.

8

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.

Murai J, Marchand C, Shahane SA, Sun H, Huang R, Zhang Y, Chergui A, Ji J, Doroshow JH, Jadhav A, Takeda S, Xia M, Pommier Y. Murai J, et al. Among authors: shahane sa. DNA Repair (Amst). 2014 Sep;21:177-82. doi: 10.1016/j.dnarep.2014.03.006. Epub 2014 Apr 29. DNA Repair (Amst). 2014. PMID: 24794403 Free PMC article.

9

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.

Huang R, Xia M, Sakamuru S, Zhao J, Shahane SA, Attene-Ramos M, Zhao T, Austin CP, Simeonov A. Huang R, et al. Among authors: shahane sa. Nat Commun. 2016 Jan 26;7:10425. doi: 10.1038/ncomms10425. Nat Commun. 2016. PMID: 26811972 Free PMC article.

10

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Nishihara K, Huang R, Zhao J, Shahane SA, Witt KL, Smith-Roe SL, Tice RR, Takeda S, Xia M. Nishihara K, et al. Among authors: shahane sa. Mutagenesis. 2016 Jan;31(1):69-81. doi: 10.1093/mutage/gev055. Epub 2015 Aug 4. Mutagenesis. 2016. PMID: 26243743 Free PMC article.

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