Harms MJ - Search Results

1

Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

Harms MJ, Thornton JW. Harms MJ, et al. Nat Rev Genet. 2013 Aug;14(8):559-71. doi: 10.1038/nrg3540. Nat Rev Genet. 2013. PMID: 23864121 Free PMC article. Review.

2

Analyzing protein structure and function using ancestral gene reconstruction.

Harms MJ, Thornton JW. Harms MJ, et al. Curr Opin Struct Biol. 2010 Jun;20(3):360-6. doi: 10.1016/j.sbi.2010.03.005. Epub 2010 Apr 21. Curr Opin Struct Biol. 2010. PMID: 20413295 Free PMC article. Review.

3

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.

Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. Bridgham JT, et al. Among authors: harms mj. PLoS Biol. 2010 Oct 5;8(10):e1000497. doi: 10.1371/journal.pbio.1000497. PLoS Biol. 2010. PMID: 20957188 Free PMC article.

4

Evolution of minimal specificity and promiscuity in steroid hormone receptors.

Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW. Eick GN, et al. Among authors: harms mj. PLoS Genet. 2012;8(11):e1003072. doi: 10.1371/journal.pgen.1003072. Epub 2012 Nov 15. PLoS Genet. 2012. PMID: 23166518 Free PMC article.

5

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.

Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. Harms MJ, et al. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11475-80. doi: 10.1073/pnas.1303930110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798447 Free PMC article.

6

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

Harms MJ, Thornton JW. Harms MJ, et al. Nature. 2014 Aug 14;512(7513):203-7. doi: 10.1038/nature13410. Epub 2014 Jun 15. Nature. 2014. PMID: 24930765 Free PMC article.

7

Thermodynamic system drift in protein evolution.

Hart KM, Harms MJ, Schmidt BH, Elya C, Thornton JW, Marqusee S. Hart KM, et al. Among authors: harms mj. PLoS Biol. 2014 Nov 11;12(11):e1001994. doi: 10.1371/journal.pbio.1001994. eCollection 2014 Nov. PLoS Biol. 2014. PMID: 25386647 Free PMC article.

8

Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family.

Wheeler LC, Donor MT, Prell JS, Harms MJ. Wheeler LC, et al. Among authors: harms mj. PLoS One. 2016 Oct 20;11(10):e0164740. doi: 10.1371/journal.pone.0164740. eCollection 2016. PLoS One. 2016. PMID: 27764152 Free PMC article.

9

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.

Eick GN, Bridgham JT, Anderson DP, Harms MJ, Thornton JW. Eick GN, et al. Among authors: harms mj. Mol Biol Evol. 2017 Feb 1;34(2):247-261. doi: 10.1093/molbev/msw223. Mol Biol Evol. 2017. PMID: 27795231 Free PMC article.

10

The thermostability and specificity of ancient proteins.

Wheeler LC, Lim SA, Marqusee S, Harms MJ. Wheeler LC, et al. Among authors: harms mj. Curr Opin Struct Biol. 2016 Jun;38:37-43. doi: 10.1016/j.sbi.2016.05.015. Epub 2016 Jun 9. Curr Opin Struct Biol. 2016. PMID: 27288744 Free PMC article. Review.

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