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scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type-specific transcriptome-wide association study framework.
Zhous Y, Adeluwa T, Zhu L, Salazar-Magaña S, Sumner S, Kim H, Gona S, Nyasimi F, Kulkarni R, Powell J, Madduri R, Liu B, Chen M, Im HK. Zhous Y, et al. Among authors: im hk. bioRxiv [Preprint]. 2024 Nov 14:2024.11.11.623049. doi: 10.1101/2024.11.11.623049. bioRxiv. 2024. PMID: 39605417 Free PMC article. Preprint.
Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Wittich H, Ardlie K, Taylor KD, Durda P, Liu Y, Mikhaylova A, Gignoux CR, Cho MH, Rich SS, Rotter JI; NHLBI TOPMed Consortium; Manichaikul A, Im HK, Wheeler HE. Wittich H, et al. Among authors: im hk. Am J Hum Genet. 2024 Mar 7;111(3):445-455. doi: 10.1016/j.ajhg.2024.01.006. Epub 2024 Feb 5. Am J Hum Genet. 2024. PMID: 38320554 Free PMC article.
Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.
Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky A. Jia G, et al. Among authors: im hk. Nat Comput Sci. 2023 Jul;3(7):658. doi: 10.1038/s43588-023-00488-1. Nat Comput Sci. 2023. PMID: 38214655 Free PMC article. No abstract available.
The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.
Jia G, Li Y, Zhong X, Wang K, Pividori M, Alomairy R, Esposito A, Ltaief H, Terao C, Akiyama M, Matsuda K, Keyes DE, Im HK, Gojobori T, Kamatani Y, Kubo M, Cox NJ, Evans J, Gao X, Rzhetsky A. Jia G, et al. Among authors: im hk. Nat Comput Sci. 2023 May;3(5):403-417. doi: 10.1038/s43588-023-00453-y. Epub 2023 May 22. Nat Comput Sci. 2023. PMID: 38177845 Free PMC article.
Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.
Araujo DS, Nguyen C, Hu X, Mikhaylova AV, Gignoux C, Ardlie K, Taylor KD, Durda P, Liu Y, Papanicolaou G, Cho MH, Rich SS, Rotter JI; NHLBI TOPMed Consortium; Im HK, Manichaikul A, Wheeler HE. Araujo DS, et al. Among authors: im hk. HGG Adv. 2023 Jul 1;4(4):100216. doi: 10.1016/j.xhgg.2023.100216. eCollection 2023 Oct 12. HGG Adv. 2023. PMID: 37869564 Free PMC article.
Revealing polygenic pleiotropy using genetic risk scores for asthma.
Dapas M, Lee YL, Wentworth-Sheilds W, Im HK, Ober C, Schoettler N. Dapas M, et al. Among authors: im hk. HGG Adv. 2023 Aug 17;4(4):100233. doi: 10.1016/j.xhgg.2023.100233. eCollection 2023 Oct 12. HGG Adv. 2023. PMID: 37663543 Free PMC article.
Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.
Gregga I, Pharoah PDP, Gayther SA, Manichaikul A, Im HK, Kar SP, Schildkraut JM, Wheeler HE. Gregga I, et al. Among authors: im hk. Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1198-1207. doi: 10.1158/1055-9965.EPI-23-0309. Cancer Epidemiol Biomarkers Prev. 2023. PMID: 37409955 Free PMC article.
Predicting molecular mechanisms of hereditary diseases by using their tissue-selective manifestation.
Simonovsky E, Sharon M, Ziv M, Mauer O, Hekselman I, Jubran J, Vinogradov E, Argov CM, Basha O, Kerber L, Yogev Y, Segrè AV, Im HK; GTEx Consortium; Birk O, Rokach L, Yeger-Lotem E. Simonovsky E, et al. Among authors: im hk. Mol Syst Biol. 2023 Aug 8;19(8):e11407. doi: 10.15252/msb.202211407. Epub 2023 May 26. Mol Syst Biol. 2023. PMID: 37232043 Free PMC article.
132 results