Weber ML - Search Results

1

Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.

Shaffer CL, Hurst RS, Scialis RJ, Osgood SM, Bryce DK, Hoffmann WE, Lazzaro JT, Hanks AN, Lotarski S, Weber ML, Liu J, Menniti FS, Schmidt CJ, Hajós M. Shaffer CL, et al. Among authors: weber ml. J Pharmacol Exp Ther. 2013 Oct;347(1):212-24. doi: 10.1124/jpet.113.204735. Epub 2013 Jul 30. J Pharmacol Exp Ther. 2013. PMID: 23899905

2

The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).

Shaffer CL, Patel NC, Schwarz J, Scialis RJ, Wei Y, Hou XJ, Xie L, Karki K, Bryce DK, Osgood SM, Hoffmann WE, Lazzaro JT, Chang C, McGinnis DF, Lotarski SM, Liu J, Obach RS, Weber ML, Chen L, Zasadny KR, Seymour PA, Schmidt CJ, Hajós M, Hurst RS, Pandit J, O'Donnell CJ. Shaffer CL, et al. Among authors: weber ml. J Med Chem. 2015 May 28;58(10):4291-308. doi: 10.1021/acs.jmedchem.5b00300. Epub 2015 May 14. J Med Chem. 2015. PMID: 25905800

3

Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors.

Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H. Weber ML, et al. Neuropharmacology. 2013 Sep;72:88-95. doi: 10.1016/j.neuropharm.2013.04.027. Epub 2013 Apr 30. Neuropharmacology. 2013. PMID: 23639435

4

Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine.

Shaffer CL, Dutra JK, Tseng WC, Weber ML, Bogart LJ, Hales K, Pang J, Volfson D, Am Ende CW, Green ME, Buhl DL. Shaffer CL, et al. Among authors: weber ml. Neuropharmacology. 2019 Jul 15;153:73-81. doi: 10.1016/j.neuropharm.2019.04.019. Epub 2019 Apr 20. Neuropharmacology. 2019. PMID: 31015046

5

Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.

Schwarz JB, Gibbons SE, Graham SR, Colbry NL, Guzzo PR, Le VD, Vartanian MG, Kinsora JJ, Lotarski SM, Li Z, Dickerson MR, Su TZ, Weber ML, El-Kattan A, Thorpe AJ, Donevan SD, Taylor CP, Wustrow DJ. Schwarz JB, et al. Among authors: weber ml. J Med Chem. 2005 Apr 21;48(8):3026-35. doi: 10.1021/jm0491086. J Med Chem. 2005. PMID: 15828841

6

Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.

Ryder TR, Hu LY, Rafferty MF, Lotarski SM, Rock DM, Stoehr SJ, Taylor CP, Weber ML, Miljanich GP, Millerman E, Szoke BG. Ryder TR, et al. Among authors: weber ml. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2453-8. doi: 10.1016/s0960-894x(99)00405-9. Bioorg Med Chem Lett. 1999. PMID: 10476886

7

Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells.

Su TZ, Feng MR, Weber ML. Su TZ, et al. Among authors: weber ml. J Pharmacol Exp Ther. 2005 Jun;313(3):1406-15. doi: 10.1124/jpet.104.082255. Epub 2005 Mar 15. J Pharmacol Exp Ther. 2005. PMID: 15769862

8

Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.

Hu LY, Ryder TR, Rafferty MF, Feng MR, Lotarski SM, Rock DM, Sinz M, Stoehr SJ, Taylor CP, Weber ML, Bowersox SS, Miljanich GP, Millerman E, Wang YX, Szoke BG. Hu LY, et al. Among authors: weber ml. J Med Chem. 1999 Oct 7;42(20):4239-49. doi: 10.1021/jm9902739. J Med Chem. 1999. PMID: 10514294

9

N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.

Hu LY, Ryder TR, Rafferty MF, Cody WL, Lotarski SM, Miljanich GP, Millerman E, Rock DM, Song Y, Stoehr SJ, Taylor CP, Weber ML, Szoke BG, Vartanian MG. Hu LY, et al. Among authors: weber ml. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. doi: 10.1016/s0960-894x(99)00100-6. Bioorg Med Chem Lett. 1999. PMID: 10206559

10

Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits.

Li Z, Taylor CP, Weber M, Piechan J, Prior F, Bian F, Cui M, Hoffman D, Donevan S. Li Z, et al. Eur J Pharmacol. 2011 Sep 30;667(1-3):80-90. doi: 10.1016/j.ejphar.2011.05.054. Epub 2011 Jun 1. Eur J Pharmacol. 2011. PMID: 21651903

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