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Page 1
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.
Martin HL, Turner AL, Higgins J, Tang AA, Tiede C, Taylor T, Siripanthong S, Adams TL, Manfield IW, Bell SM, Morrison EE, Bond J, Trinh CH, Hurst CD, Knowles MA, Bayliss RW, Tomlinson DC. Martin HL, et al. Among authors: manfield iw. Cell Rep. 2023 Oct 31;42(10):113184. doi: 10.1016/j.celrep.2023.113184. Epub 2023 Sep 29. Cell Rep. 2023. PMID: 37776520 Free article.
Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles.
Roberts SE, Martin HL, Al-Qallaf D, Tang AA, Tiede C, Gaule TG, Dobon-Alonso A, Overman R, Shah S, Peyret H, Saunders K, Bon R, Manfield IW, Bell SM, Lomonossoff GP, Speirs V, Tomlinson DC. Roberts SE, et al. Among authors: manfield iw. iScience. 2024 Jul 5;27(8):110461. doi: 10.1016/j.isci.2024.110461. eCollection 2024 Aug 16. iScience. 2024. PMID: 39104409 Free PMC article.
Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid.
Stockley PG, White SJ, Dykeman E, Manfield I, Rolfsson O, Patel N, Bingham R, Barker A, Wroblewski E, Chandler-Bostock R, Weiß EU, Ranson NA, Tuma R, Twarock R. Stockley PG, et al. Among authors: manfield i. Bacteriophage. 2016 Mar 2;6(1):e1157666. doi: 10.1080/21597081.2016.1157666. eCollection 2016 Jan-Mar. Bacteriophage. 2016. PMID: 27144089 Free PMC article.
Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.
Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. Chai G, et al. Neuron. 2021 Jan 20;109(2):241-256.e9. doi: 10.1016/j.neuron.2020.10.035. Epub 2020 Nov 20. Neuron. 2021. PMID: 33220177 Free PMC article.
Probing met repressor-operator recognition in solution.
He YY, McNally T, Manfield I, Navratil O, Old IG, Phillips SE, Saint-Girons I, Stockley PG. He YY, et al. Among authors: manfield i. Nature. 1992 Oct 1;359(6394):431-3. doi: 10.1038/359431a0. Nature. 1992. PMID: 1406957
Cooperative tandem binding of met repressor of Escherichia coli.
Phillips SE, Manfield I, Parsons I, Davidson BE, Rafferty JB, Somers WS, Margarita D, Cohen GN, Saint-Girons I, Stockley PG. Phillips SE, et al. Among authors: manfield i. Nature. 1989 Oct 26;341(6244):711-5. doi: 10.1038/341711a0. Nature. 1989. PMID: 2677754
55 results