Graham MJ - Search Results

1

Modulation of lipoprotein metabolism by antisense technology: preclinical drug discovery methodology.

Crooke RM, Graham MJ. Crooke RM, et al. Among authors: graham mj. Methods Mol Biol. 2013;1027:309-24. doi: 10.1007/978-1-60327-369-5_14. Methods Mol Biol. 2013. PMID: 23912993

2

In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides.

Crooke RM, Graham MJ, Cooke ME, Crooke ST. Crooke RM, et al. Among authors: graham mj. J Pharmacol Exp Ther. 1995 Oct;275(1):462-73. J Pharmacol Exp Ther. 1995. PMID: 7562586

3

Tritium labeling of antisense oligonucleotides by exchange with tritiated water.

Graham MJ, Freier SM, Crooke RM, Ecker DJ, Maslova RN, Lesnik EA. Graham MJ, et al. Nucleic Acids Res. 1993 Aug 11;21(16):3737-43. doi: 10.1093/nar/21.16.3737. Nucleic Acids Res. 1993. PMID: 8367289 Free PMC article.

4

Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications.

McKay RA, Cummins LL, Graham MJ, Lesnik EA, Owens SR, Winniman M, Dean NM. McKay RA, et al. Among authors: graham mj. Nucleic Acids Res. 1996 Feb 1;24(3):411-7. doi: 10.1093/nar/24.3.411. Nucleic Acids Res. 1996. PMID: 8602351 Free PMC article.

5

Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin.

Crooke RM, Crooke ST, Graham MJ, Cooke ME. Crooke RM, et al. Among authors: graham mj. Toxicol Appl Pharmacol. 1996 Sep;140(1):85-93. doi: 10.1006/taap.1996.0200. Toxicol Appl Pharmacol. 1996. PMID: 8806873

6

In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.

Graham MJ, Crooke ST, Monteith DK, Cooper SR, Lemonidis KM, Stecker KK, Martin MJ, Crooke RM. Graham MJ, et al. J Pharmacol Exp Ther. 1998 Jul;286(1):447-58. J Pharmacol Exp Ther. 1998. PMID: 9655890

7

Metabolism of antisense oligonucleotides in rat liver homogenates.

Crooke RM, Graham MJ, Martin MJ, Lemonidis KM, Wyrzykiewiecz T, Cummins LL. Crooke RM, et al. Among authors: graham mj. J Pharmacol Exp Ther. 2000 Jan;292(1):140-9. J Pharmacol Exp Ther. 2000. PMID: 10604941

8

Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice.

Butler M, Crooke RM, Graham MJ, Lemonidis KM, Lougheed M, Murray SF, Witchell D, Steinbrecher U, Bennett CF. Butler M, et al. Among authors: graham mj. J Pharmacol Exp Ther. 2000 Feb;292(2):489-96. J Pharmacol Exp Ther. 2000. PMID: 10640284

9

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

Yu RZ, Zhang H, Geary RS, Graham M, Masarjian L, Lemonidis K, Crooke R, Dean NM, Levin AA. Yu RZ, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):388-95. J Pharmacol Exp Ther. 2001. PMID: 11160622

10

Variations in mRNA content have no effect on the potency of antisense oligonucleotides.

Miraglia L, Watt AT, Graham MJ, Crooke ST. Miraglia L, et al. Among authors: graham mj. Antisense Nucleic Acid Drug Dev. 2000 Dec;10(6):453-61. doi: 10.1089/oli.1.2000.10.453. Antisense Nucleic Acid Drug Dev. 2000. PMID: 11198929

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