Weston H - Search Results

1

Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.

Shah SK, Brause KA, Chandler GO, Finke PE, Ashe BM, Weston H, Knight WB, Maycock AL, Doherty JB. Shah SK, et al. Among authors: weston h. J Med Chem. 1990 Sep;33(9):2529-35. doi: 10.1021/jm00171a030. J Med Chem. 1990. PMID: 2391693

2

Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones.

Shah SK, Dorn CP Jr, Finke PE, Hale JJ, Hagmann WK, Brause KA, Chandler GO, Kissinger AL, Ashe BM, Weston H, et al. Shah SK, et al. Among authors: weston h. J Med Chem. 1992 Oct 16;35(21):3745-54. doi: 10.1021/jm00099a003. J Med Chem. 1992. PMID: 1433189

3

Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase.

Knight WB, Green BG, Chabin RM, Gale P, Maycock AL, Weston H, Kuo DW, Westler WM, Dorn CP, Finke PE, et al. Knight WB, et al. Among authors: weston h. Biochemistry. 1992 Sep 8;31(35):8160-70. doi: 10.1021/bi00150a007. Biochemistry. 1992. PMID: 1525156

4

Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives.

Knight WB, Maycock AL, Green BG, Ashe BM, Gale P, Weston H, Finke PE, Hagmann WK, Shah SK, Doherty JB. Knight WB, et al. Among authors: weston h. Biochemistry. 1992 Jun 2;31(21):4980-6. doi: 10.1021/bi00136a010. Biochemistry. 1992. PMID: 1599924

5

PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.

Green BG, Weston H, Ashe BM, Doherty J, Finke P, Hagmann W, Lark M, Mao J, Maycock A, Moore V, et al. Green BG, et al. Among authors: weston h. Arch Biochem Biophys. 1991 Apr;286(1):284-92. doi: 10.1016/0003-9861(91)90042-h. Arch Biochem Biophys. 1991. PMID: 1897955

6

Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.

Finke PE, Ashe BM, Knight WB, Maycock AL, Navia MA, Shah SK, Thompson KR, Underwood DJ, Weston H, Zimmerman M, et al. Finke PE, et al. Among authors: weston h. J Med Chem. 1990 Sep;33(9):2522-8. doi: 10.1021/jm00171a029. J Med Chem. 1990. PMID: 2391692

7

Mechanism of inhibition of human leucocyte elastase by monocyclic beta-lactams.

Chabin R, Green BG, Gale P, Maycock AL, Weston H, Dorn CP, Finke PE, Hagmann WK, Hale JJ, MacCoss M, et al. Chabin R, et al. Among authors: weston h. Biochemistry. 1993 Aug 31;32(34):8970-80. doi: 10.1021/bi00085a031. Biochemistry. 1993. PMID: 8364042

8

Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution.

Hagmann WK, Kissinger AL, Shah SK, Finke PE, Dorn CP, Brause KA, Ashe BM, Weston H, Maycock AL, Knight WB, et al. Hagmann WK, et al. Among authors: weston h. J Med Chem. 1993 Mar 19;36(6):771-7. doi: 10.1021/jm00058a015. J Med Chem. 1993. PMID: 8459404

9

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.

Smith PW, Sollis SL, Howes PD, Cherry PC, Starkey ID, Cobley KN, Weston H, Scicinski J, Merritt A, Whittington A, Wyatt P, Taylor N, Green D, Bethell R, Madar S, Fenton RJ, Morley PJ, Pateman T, Beresford A. Smith PW, et al. Among authors: weston h. J Med Chem. 1998 Mar 12;41(6):787-97. doi: 10.1021/jm970374b. J Med Chem. 1998. PMID: 9526555

10

Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.

Chan C, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chaudry L, Chung CW, Convery MA, Hamblin JN, Johnstone L, Kelly HA, Kleanthous S, Patikis A, Patel C, Pateman AJ, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Whitworth C, Young RJ, Zhou P. Chan C, et al. J Med Chem. 2007 Apr 5;50(7):1546-57. doi: 10.1021/jm060870c. Epub 2007 Mar 6. J Med Chem. 2007. PMID: 17338508

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