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Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo.
Renshaw J, Taylor KR, Bishop R, Valenti M, De Haven Brandon A, Gowan S, Eccles SA, Ruddle RR, Johnson LD, Raynaud FI, Selfe JL, Thway K, Pietsch T, Pearson AD, Shipley J. Renshaw J, et al. Among authors: shipley j. Clin Cancer Res. 2013 Nov 1;19(21):5940-51. doi: 10.1158/1078-0432.CCR-13-0850. Epub 2013 Aug 5. Clin Cancer Res. 2013. PMID: 23918606 Free PMC article.
Role for amplification and expression of glypican-5 in rhabdomyosarcoma.
Williamson D, Selfe J, Gordon T, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P, Shipley J. Williamson D, et al. Among authors: shipley j. Cancer Res. 2007 Jan 1;67(1):57-65. doi: 10.1158/0008-5472.CAN-06-1650. Cancer Res. 2007. PMID: 17210683 Free article.
Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.
Missiaglia E, Selfe J, Hamdi M, Williamson D, Schaaf G, Fang C, Koster J, Summersgill B, Messahel B, Versteeg R, Pritchard-Jones K, Kool M, Shipley J. Missiaglia E, et al. Among authors: shipley j. Genes Chromosomes Cancer. 2009 Jun;48(6):455-67. doi: 10.1002/gcc.20655. Genes Chromosomes Cancer. 2009. PMID: 19235922
Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.
Williamson D, Missiaglia E, de Reyniès A, Pierron G, Thuille B, Palenzuela G, Thway K, Orbach D, Laé M, Fréneaux P, Pritchard-Jones K, Oberlin O, Shipley J, Delattre O. Williamson D, et al. Among authors: shipley j. J Clin Oncol. 2010 May 1;28(13):2151-8. doi: 10.1200/JCO.2009.26.3814. Epub 2010 Mar 29. J Clin Oncol. 2010. PMID: 20351326
MicroRNA-206 expression levels correlate with clinical behaviour of rhabdomyosarcomas.
Missiaglia E, Shepherd CJ, Patel S, Thway K, Pierron G, Pritchard-Jones K, Renard M, Sciot R, Rao P, Oberlin O, Delattre O, Shipley J. Missiaglia E, et al. Among authors: shipley j. Br J Cancer. 2010 Jun 8;102(12):1769-77. doi: 10.1038/sj.bjc.6605684. Epub 2010 May 25. Br J Cancer. 2010. PMID: 20502458 Free PMC article.
Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy.
Tonelli R, McIntyre A, Camerin C, Walters ZS, Di Leo K, Selfe J, Purgato S, Missiaglia E, Tortori A, Renshaw J, Astolfi A, Taylor KR, Serravalle S, Bishop R, Nanni C, Valentijn LJ, Faccini A, Leuschner I, Formica S, Reis-Filho JS, Ambrosini V, Thway K, Franzoni M, Summersgill B, Marchelli R, Hrelia P, Cantelli-Forti G, Fanti S, Corradini R, Pession A, Shipley J. Tonelli R, et al. Among authors: shipley j. Clin Cancer Res. 2012 Feb 1;18(3):796-807. doi: 10.1158/1078-0432.CCR-11-1981. Epub 2011 Nov 7. Clin Cancer Res. 2012. PMID: 22065083
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