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A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection.
Preston SP, Allison CC, Schaefer J, Clow W, Bader SM, Collard S, Forsyth WO, Clark MP, Garnham AL, Li-Wai-Suen CSN, Peiris T, Teale J, Mackiewicz L, Davidson S, Doerflinger M, Pellegrini M. Preston SP, et al. Among authors: clark mp. Cell Death Dis. 2023 Feb 15;14(2):123. doi: 10.1038/s41419-023-05635-0. Cell Death Dis. 2023. PMID: 36792599 Free PMC article.
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.
Bader SM, Preston SP, Saliba K, Lipszyc A, Grant ZL, Mackiewicz L, Baldi A, Hempel A, Clark MP, Peiris T, Clow W, Bjelic J, Stutz MD, Arandjelovic P, Teale J, Du F, Coultas L, Murphy JM, Allison CC, Pellegrini M, Samson AL. Bader SM, et al. Among authors: clark mp. Cell Death Differ. 2023 Jan;30(1):27-36. doi: 10.1038/s41418-022-01042-8. Epub 2022 Jul 23. Cell Death Differ. 2023. PMID: 35871233 Free PMC article.
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage.
Teh CE, Preston SP, Robbins AK, Stutz MD, Cooney J, Clark MP, Policheni AN, Allison CC, Mackiewicz L, Arandjelovic P, Ebert G, Doerflinger M, Tan T, Rankin LC, Teh PP, Belz GT, Kallies A, Strasser A, Pellegrini M, Gray DHD. Teh CE, et al. Among authors: clark mp. Sci Immunol. 2022 Mar 25;7(69):eabn8041. doi: 10.1126/sciimmunol.abn8041. Epub 2022 Mar 25. Sci Immunol. 2022. PMID: 35333545
Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1.
Boyd MJ, Collier PN, Clark MP, Deng H, Kesavan S, Ronkin SM, Waal N, Wang J, Cao J, Li P, Come J, Davies I, Duffy JP, Cochran JE, Court JJ, Chandupatla K, Jackson KL, Maltais F, O'Dowd H, Boucher C, Considine T, Taylor WP, Gao H, Chakilam A, Engtrakul J, Crawford D, Doyle E, Phillips J, Kemper R, Swett R, Empfield J, Bunnage ME, Charifson PS, Magavi SS. Boyd MJ, et al. Among authors: clark mp. J Med Chem. 2021 Dec 23;64(24):17777-17794. doi: 10.1021/acs.jmedchem.1c00948. Epub 2021 Dec 6. J Med Chem. 2021. PMID: 34871500
82 results