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Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A. Barter ZE, et al. Among authors: boobis ar. Curr Drug Metab. 2007 Jan;8(1):33-45. doi: 10.2174/138920007779315053. Curr Drug Metab. 2007. PMID: 17266522 Review.
Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological relevance of tumour type, data quality and uncertainty assessment.
Edler L, Hart A, Greaves P, Carthew P, Coulet M, Boobis A, Williams GM, Smith B. Edler L, et al. Food Chem Toxicol. 2014 Aug;70:264-89. doi: 10.1016/j.fct.2013.10.030. Epub 2013 Oct 29. Food Chem Toxicol. 2014. PMID: 24176677 Free article.
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
Salonen JS, Nyman L, Boobis AR, Edwards RJ, Watts P, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF, Taavitsainen P, Pelkonen O. Salonen JS, et al. Among authors: boobis ar. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093. Drug Metab Dispos. 2003. PMID: 12920164
Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space.
Yang C, Barlow SM, Muldoon Jacobs KL, Vitcheva V, Boobis AR, Felter SP, Arvidson KB, Keller D, Cronin MTD, Enoch S, Worth A, Hollnagel HM. Yang C, et al. Among authors: boobis ar. Food Chem Toxicol. 2017 Nov;109(Pt 1):170-193. doi: 10.1016/j.fct.2017.08.043. Epub 2017 Sep 1. Food Chem Toxicol. 2017. PMID: 28867342 Free article.
Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans.
Cohen SM, Boobis AR, Dellarco VL, Doe JE, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Wolf DC. Cohen SM, et al. Among authors: boobis ar. Regul Toxicol Pharmacol. 2019 Apr;103:100-105. doi: 10.1016/j.yrtph.2019.01.017. Epub 2019 Jan 8. Regul Toxicol Pharmacol. 2019. PMID: 30634021 Free article. Review.
354 results