Smith WL - Search Results

1

Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.

Dong L, Sharma NP, Jurban BJ, Smith WL. Dong L, et al. Among authors: smith wl. J Biol Chem. 2013 Oct 4;288(40):28641-55. doi: 10.1074/jbc.M113.505503. Epub 2013 Aug 16. J Biol Chem. 2013. PMID: 23955344 Free PMC article.

2

Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.

Sharma NP, Dong L, Yuan C, Noon KR, Smith WL. Sharma NP, et al. Among authors: smith wl. Mol Pharmacol. 2010 Jun;77(6):979-86. doi: 10.1124/mol.109.063115. Epub 2010 Mar 1. Mol Pharmacol. 2010. PMID: 20194532 Free PMC article.

3

Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.

Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG, Smith WL. Dong L, et al. Among authors: smith wl. J Biol Chem. 2011 May 27;286(21):19035-46. doi: 10.1074/jbc.M111.231969. Epub 2011 Apr 5. J Biol Chem. 2011. PMID: 21467029 Free PMC article.

4

Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis.

Dong L, Zou H, Yuan C, Hong YH, Kuklev DV, Smith WL. Dong L, et al. Among authors: smith wl. J Biol Chem. 2016 Feb 19;291(8):4069-78. doi: 10.1074/jbc.M115.698001. Epub 2015 Dec 23. J Biol Chem. 2016. PMID: 26703471 Free PMC article.

5

Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.

Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL. Dong L, et al. Among authors: smith wl. J Biol Chem. 2016 Dec 2;291(49):25641-25655. doi: 10.1074/jbc.M116.757310. Epub 2016 Oct 18. J Biol Chem. 2016. PMID: 27756840 Free PMC article.

6

Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1.

Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi BR, Smith WL. Rimon G, et al. Among authors: smith wl. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):28-33. doi: 10.1073/pnas.0909765106. Epub 2009 Dec 1. Proc Natl Acad Sci U S A. 2010. PMID: 19955429 Free PMC article.

7

Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids.

Zou H, Yuan C, Dong L, Sidhu RS, Hong YH, Kuklev DV, Smith WL. Zou H, et al. Among authors: smith wl. J Lipid Res. 2012 Jul;53(7):1336-47. doi: 10.1194/jlr.M026856. Epub 2012 Apr 30. J Lipid Res. 2012. PMID: 22547204 Free PMC article.

8

Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.

Dong L, Zou H, Yuan C, Hong YH, Uhlson CL, Murphy RC, Smith WL. Dong L, et al. Among authors: smith wl. J Lipid Res. 2016 Jun;57(6):1043-50. doi: 10.1194/jlr.M067512. Epub 2016 Apr 8. J Lipid Res. 2016. PMID: 27059979 Free PMC article.

9

Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2.

Smith WL, Malkowski MG. Smith WL, et al. J Biol Chem. 2019 Feb 1;294(5):1697-1705. doi: 10.1074/jbc.TM118.006295. J Biol Chem. 2019. PMID: 30710016 Free PMC article. Review.

10

Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases.

Seibold SA, Ball T, Hsi LC, Mills DA, Abeysinghe RD, Micielli R, Rieke CJ, Cukier RI, Smith WL. Seibold SA, et al. Among authors: smith wl. J Biol Chem. 2003 Nov 14;278(46):46163-70. doi: 10.1074/jbc.M306319200. Epub 2003 Sep 2. J Biol Chem. 2003. PMID: 12952981 Free article.

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