Schmidt WK - Search Results

1

Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies.

Hildebrandt ER, Davis DM, Deaton J, Krishnankutty RK, Lilla E, Schmidt WK. Hildebrandt ER, et al. Among authors: schmidt wk. Biochemistry. 2013 Sep 24;52(38):6601-14. doi: 10.1021/bi400647c. Epub 2013 Sep 10. Biochemistry. 2013. PMID: 23972033 Free PMC article.

2

Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.

Plummer LJ, Hildebrandt ER, Porter SB, Rogers VA, McCracken J, Schmidt WK. Plummer LJ, et al. Among authors: schmidt wk. J Biol Chem. 2006 Feb 24;281(8):4596-605. doi: 10.1074/jbc.M506284200. Epub 2005 Dec 17. J Biol Chem. 2006. PMID: 16361710 Free PMC article.

3

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

Porter SB, Hildebrandt ER, Breevoort SR, Mokry DZ, Dore TM, Schmidt WK. Porter SB, et al. Among authors: schmidt wk. Biochim Biophys Acta. 2007 Jun;1773(6):853-62. doi: 10.1016/j.bbamcr.2007.03.004. Epub 2007 Mar 20. Biochim Biophys Acta. 2007. PMID: 17467817 Free PMC article.

4

Small-molecule inhibitors of the Rce1p CaaX protease.

Manandhar SP, Hildebrandt ER, Schmidt WK. Manandhar SP, et al. Among authors: schmidt wk. J Biomol Screen. 2007 Oct;12(7):983-93. doi: 10.1177/1087057107307226. J Biomol Screen. 2007. PMID: 17942791 Free PMC article.

5

Proteolytic processing of certain CaaX motifs can occur in the absence of the Rce1p and Ste24p CaaX proteases.

Krishnankutty RK, Kukday SS, Castleberry AJ, Breevoort SR, Schmidt WK. Krishnankutty RK, et al. Among authors: schmidt wk. Yeast. 2009 Aug;26(8):451-63. doi: 10.1002/yea.1678. Yeast. 2009. PMID: 19504624 Free PMC article.

6

Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.

Manandhar SP, Hildebrandt ER, Jacobsen WH, Santangelo GM, Schmidt WK. Manandhar SP, et al. Among authors: schmidt wk. Yeast. 2010 Jun;27(6):327-43. doi: 10.1002/yea.1756. Yeast. 2010. PMID: 20162532 Free PMC article.

7

Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate.

Kyro K, Manandhar SP, Mullen D, Schmidt WK, Distefano MD. Kyro K, et al. Among authors: schmidt wk. Bioorg Med Chem. 2010 Aug 1;18(15):5675-84. doi: 10.1016/j.bmc.2010.06.024. Epub 2010 Jun 12. Bioorg Med Chem. 2010. PMID: 20619662 Free PMC article.

8

Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.

Dechert AM, MacNamara JP, Breevoort SR, Hildebrandt ER, Hembree NW, Rea AC, McLain DE, Porter SB, Schmidt WK, Dore TM. Dechert AM, et al. Among authors: schmidt wk. Bioorg Med Chem. 2010 Sep 1;18(17):6230-7. doi: 10.1016/j.bmc.2010.07.041. Epub 2010 Jul 21. Bioorg Med Chem. 2010. PMID: 20696584 Free PMC article.

9

Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications.

Kyro K, Manandhar SP, Mullen D, Schmidt WK, Distefano MD. Kyro K, et al. Among authors: schmidt wk. Bioorg Med Chem. 2011 Dec 15;19(24):7559-69. doi: 10.1016/j.bmc.2011.10.027. Epub 2011 Oct 18. Bioorg Med Chem. 2011. PMID: 22079863 Free PMC article.

10

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

Mohammed I, Hampton SE, Ashall L, Hildebrandt ER, Kutlik RA, Manandhar SP, Floyd BJ, Smith HE, Dozier JK, Distefano MD, Schmidt WK, Dore TM. Mohammed I, et al. Among authors: schmidt wk. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. doi: 10.1016/j.bmc.2015.11.043. Epub 2015 Nov 30. Bioorg Med Chem. 2016. PMID: 26706114 Free PMC article.

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