Ulven T - Search Results

1

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G. Hudson BD, et al. Among authors: ulven t. Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26. Mol Pharmacol. 2013. PMID: 23979972 Free PMC article.

2

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A, Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T. Christiansen E, et al. Among authors: ulven t. J Med Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. J Med Chem. 2008. PMID: 18947221

3

A rapid and efficient Sonogashira protocol and improved synthesis of free fatty acid 1 (FFA1) receptor agonists.

Christiansen E, Due-Hansen ME, Ulven T. Christiansen E, et al. Among authors: ulven t. J Org Chem. 2010 Feb 19;75(4):1301-4. doi: 10.1021/jo902533p. J Org Chem. 2010. PMID: 20099863

4

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: ulven t. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

5

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

Schmidt J, Liebscher K, Merten N, Grundmann M, Mielenz M, Sauerwein H, Christiansen E, Due-Hansen ME, Ulven T, Ullrich S, Gomeza J, Drewke C, Kostenis E. Schmidt J, et al. Among authors: ulven t. J Biol Chem. 2011 Apr 8;286(14):11890-4. doi: 10.1074/jbc.C110.200477. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339298 Free PMC article.

6

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR, Milligan G. Smith NJ, et al. Among authors: ulven t. Mol Pharmacol. 2011 Jul;80(1):163-73. doi: 10.1124/mol.110.070789. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498659 Free PMC article.

7

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Christiansen E, Urban C, Grundmann M, Due-Hansen ME, Hagesaether E, Schmidt J, Pardo L, Ullrich S, Kostenis E, Kassack M, Ulven T. Christiansen E, et al. Among authors: ulven t. J Med Chem. 2011 Oct 13;54(19):6691-703. doi: 10.1021/jm2005699. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21854074

8

Discovery of a potent and selective GPR120 agonist.

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T. Shimpukade B, et al. Among authors: ulven t. J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2. J Med Chem. 2012. PMID: 22519963

9

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schröder R, Hudson BD, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: ulven t. J Med Chem. 2012 Jul 26;55(14):6624-8. doi: 10.1021/jm3002026. Epub 2012 Jul 13. J Med Chem. 2012. PMID: 22724451

10

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

Hudson BD, Christiansen E, Tikhonova IG, Grundmann M, Kostenis E, Adams DR, Ulven T, Milligan G. Hudson BD, et al. Among authors: ulven t. FASEB J. 2012 Dec;26(12):4951-65. doi: 10.1096/fj.12-213314. Epub 2012 Aug 23. FASEB J. 2012. PMID: 22919070 Free PMC article.

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