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Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.
Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Parra V, et al. Among authors: jana f. Diabetes. 2014 Jan;63(1):75-88. doi: 10.2337/db13-0340. Epub 2013 Sep 5. Diabetes. 2014. PMID: 24009260 Free PMC article.
Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice.
Jara JA, Castro-Castillo V, Saavedra-Olavarría J, Peredo L, Pavanni M, Jaña F, Letelier ME, Parra E, Becker MI, Morello A, Kemmerling U, Maya JD, Ferreira J. Jara JA, et al. Among authors: jana f. J Med Chem. 2014 Mar 27;57(6):2440-54. doi: 10.1021/jm500174v. Epub 2014 Mar 17. J Med Chem. 2014. PMID: 24568614
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.
Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C. Carreras-Sureda A, et al. Among authors: jana f. Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20. Nat Cell Biol. 2019. PMID: 31110288 Free PMC article.
Complex I and II are required for normal mitochondrial Ca2+ homeostasis.
Jaña F, Bustos G, Rivas J, Cruz P, Urra F, Basualto-Alarcón C, Sagredo E, Ríos M, Lovy A, Dong Z, Cerda O, Madesh M, Cárdenas C. Jaña F, et al. Mitochondrion. 2019 Nov;49:73-82. doi: 10.1016/j.mito.2019.07.004. Epub 2019 Jul 13. Mitochondrion. 2019. PMID: 31310854 Free PMC article.
21 results