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Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
Balzarini J, François KO, Van Laethem K, Hoorelbeke B, Renders M, Auwerx J, Liekens S, Oki T, Igarashi Y, Schols D. Balzarini J, et al. Among authors: schols d. Antimicrob Agents Chemother. 2010 Apr;54(4):1425-35. doi: 10.1128/AAC.01347-09. Epub 2010 Jan 4. Antimicrob Agents Chemother. 2010. PMID: 20047920 Free PMC article.
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope.
Hoorelbeke B, Huskens D, Férir G, François KO, Takahashi A, Van Laethem K, Schols D, Tanaka H, Balzarini J. Hoorelbeke B, et al. Among authors: schols d. Antimicrob Agents Chemother. 2010 Aug;54(8):3287-301. doi: 10.1128/AAC.00254-10. Epub 2010 May 24. Antimicrob Agents Chemother. 2010. PMID: 20498311 Free PMC article.
A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro.
Kaptein SJ, De Burghgraeve T, Froeyen M, Pastorino B, Alen MM, Mondotte JA, Herdewijn P, Jacobs M, de Lamballerie X, Schols D, Gamarnik AV, Sztaricskai F, Neyts J. Kaptein SJ, et al. Among authors: schols d. Antimicrob Agents Chemother. 2010 Dec;54(12):5269-80. doi: 10.1128/AAC.00686-10. Epub 2010 Sep 13. Antimicrob Agents Chemother. 2010. PMID: 20837762 Free PMC article.
DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.
Hijazi K, Wang Y, Scala C, Jeffs S, Longstaff C, Stieh D, Haggarty B, Vanham G, Schols D, Balzarini J, Jones IM, Hoxie J, Shattock R, Kelly CG. Hijazi K, et al. Among authors: schols d. PLoS One. 2011;6(12):e28307. doi: 10.1371/journal.pone.0028307. Epub 2011 Dec 7. PLoS One. 2011. PMID: 22163292 Free PMC article.
499 results