Brown H - Search Results

1

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.

Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. Ayers J, et al. Among authors: brown h. J Neurochem. 2014 Jan;128(2):305-14. doi: 10.1111/jnc.12451. Epub 2013 Oct 21. J Neurochem. 2014. PMID: 24032979 Free PMC article.

2

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1.

Qualls DA, Prudencio M, Roberts BL, Crosby K, Brown H, Borchelt DR. Qualls DA, et al. Among authors: brown h. Mol Neurodegener. 2013 Dec 17;8:46. doi: 10.1186/1750-1326-8-46. Mol Neurodegener. 2013. PMID: 24341866 Free PMC article.

3

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. Xu G, et al. Among authors: brown h. Hum Mol Genet. 2015 Feb 15;24(4):1019-35. doi: 10.1093/hmg/ddu517. Epub 2014 Oct 9. Hum Mol Genet. 2015. PMID: 25305079 Free PMC article.

4

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.

Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. Xu G, et al. Among authors: brown h. J Neurochem. 2015 May;133(3):452-64. doi: 10.1111/jnc.13022. Epub 2015 Jan 26. J Neurochem. 2015. PMID: 25557022 Free PMC article.

5

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.

Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. Ayers JI, et al. Among authors: brown h. J Neurochem. 2017 Jan;140(1):140-150. doi: 10.1111/jnc.13864. Epub 2016 Nov 25. J Neurochem. 2017. PMID: 27727458 Free PMC article.

6

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.

Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR. Crosby K, et al. Among authors: brown h. PLoS One. 2018 Nov 6;13(11):e0206751. doi: 10.1371/journal.pone.0206751. eCollection 2018. PLoS One. 2018. PMID: 30399166 Free PMC article.

7

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.

Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. Crown AM, et al. Among authors: brown h. G3 (Bethesda). 2019 Mar 7;9(3):719-728. doi: 10.1534/g3.118.200787. G3 (Bethesda). 2019. PMID: 30622123 Free PMC article.

8

A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo.

Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. Prudencio M, et al. Among authors: brown hh. J Neurochem. 2012 May;121(3):475-85. doi: 10.1111/j.1471-4159.2012.07690.x. Epub 2012 Mar 20. J Neurochem. 2012. PMID: 22332887 Free PMC article.

9

Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assemblies.

Brown HH, Borchelt DR. Brown HH, et al. PLoS One. 2014 Aug 14;9(8):e104583. doi: 10.1371/journal.pone.0104583. eCollection 2014. PLoS One. 2014. PMID: 25121776 Free PMC article.

10

An analysis of interactions between fluorescently-tagged mutant and wild-type SOD1 in intracellular inclusions.

Qualls DA, Crosby K, Brown H, Borchelt DR. Qualls DA, et al. Among authors: brown h. PLoS One. 2013 Dec 31;8(12):e83981. doi: 10.1371/journal.pone.0083981. eCollection 2013. PLoS One. 2013. PMID: 24391857 Free PMC article.

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