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A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. Wei K, et al. Among authors: mithieux g. Nat Med. 2013 Oct;19(10):1331-1337. doi: 10.1038/nm.3295. Epub 2013 Sep 15. Nat Med. 2013. PMID: 24037094 Free PMC article.
Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding.
Daniele N, Rajas F, Payrastre B, Mauco G, Zitoun C, Mithieux G. Daniele N, et al. Among authors: mithieux g. J Biol Chem. 1999 Feb 5;274(6):3597-601. doi: 10.1074/jbc.274.6.3597. J Biol Chem. 1999. PMID: 9920907 Free article.
This process, via the lipid products of PI3K, which are potent inhibitors of glucose-6-phosphatase (Mithieux, G., Daniele, N., Payrastre, B., and Zitoun, C. (1998) J. Biol. Chem. 273, 17-19), may account for the inhibition of the enzyme and participate to the inhibi …
This process, via the lipid products of PI3K, which are potent inhibitors of glucose-6-phosphatase (Mithieux, G., Daniele, N., …
181 results