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The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns.
Türbachova I, Schwachula T, Vasconcelos I, Mustea A, Baldinger T, Jones KA, Bujard H, Olek A, Olek K, Gellhaus K, Braicu I, Könsgen D, Fryer C, Ravot E, Hellwag A, Westerfeld N, Gruss OJ, Meissner M, Hasan MT, Weber M, Hoffmüller U, Zimmermann S, Loddenkemper C, Mahner S, Babel N, Berns E, Adams R, Zeilinger R, Baron U, Vergote I, Maughan T, Marme F, Dickhaus T, Sehouli J, Olek S. Türbachova I, et al. Among authors: gellhaus k. Epigenetics. 2013 Nov;8(11):1226-35. doi: 10.4161/epi.26334. Epub 2013 Sep 26. Epigenetics. 2013. PMID: 24071829 Free article.
BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).
Ruscito I, Dimitrova D, Vasconcelos I, Gellhaus K, Schwachula T, Bellati F, Zeillinger R, Benedetti-Panici P, Vergote I, Mahner S, Cacsire-Tong D, Concin N, Darb-Esfahani S, Lambrechts S, Sehouli J, Olek S, Braicu EI. Ruscito I, et al. Among authors: gellhaus k. Eur J Cancer. 2014 Aug;50(12):2090-8. doi: 10.1016/j.ejca.2014.05.001. Epub 2014 Jun 2. Eur J Cancer. 2014. PMID: 24889916
Specifications of qPCR based epigenetic immune cell quantification.
Schildknecht K, Samans B, Gussmann J, Baron U, Raschke E, Babel N, Oppatt J, Gellhaus K, Rossello A, Janack I, Olek S. Schildknecht K, et al. Among authors: gellhaus k. Clin Chem Lab Med. 2023 Nov 21;62(4):615-626. doi: 10.1515/cclm-2023-1056. Print 2024 Mar 25. Clin Chem Lab Med. 2023. PMID: 37982750 Free article.