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A mouse model that recapitulates cardinal features of the 15q13.3 microdeletion syndrome including schizophrenia- and epilepsy-related alterations.
Fejgin K, Nielsen J, Birknow MR, Bastlund JF, Nielsen V, Lauridsen JB, Stefansson H, Steinberg S, Sorensen HB, Mortensen TE, Larsen PH, Klewe IV, Rasmussen SV, Stefansson K, Werge TM, Kallunki P, Christensen KV, Didriksen M. Fejgin K, et al. Among authors: nielsen j, nielsen v. Biol Psychiatry. 2014 Jul 15;76(2):128-37. doi: 10.1016/j.biopsych.2013.08.014. Epub 2013 Oct 3. Biol Psychiatry. 2014. PMID: 24090792
A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment.
Nilsson SRO, Celada P, Fejgin K, Thelin J, Nielsen J, Santana N, Heath CJ, Larsen PH, Nielsen V, Kent BA, Saksida LM, Stensbøl TB, Robbins TW, Bastlund JF, Bussey TJ, Artigas F, Didriksen M. Nilsson SRO, et al. Among authors: nielsen j, nielsen v. Psychopharmacology (Berl). 2016 Jun;233(11):2151-2163. doi: 10.1007/s00213-016-4265-2. Epub 2016 Mar 17. Psychopharmacology (Berl). 2016. PMID: 26983414 Free PMC article.
Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice.
Didriksen M, Fejgin K, Nilsson SR, Birknow MR, Grayton HM, Larsen PH, Lauridsen JB, Nielsen V, Celada P, Santana N, Kallunki P, Christensen KV, Werge TM, Stensbøl TB, Egebjerg J, Gastambide F, Artigas F, Bastlund JF, Nielsen J. Didriksen M, et al. Among authors: nielsen j, nielsen v. J Psychiatry Neurosci. 2017 Jan;42(1):48-58. doi: 10.1503/jpn.150381. J Psychiatry Neurosci. 2017. PMID: 27391101 Free PMC article.
A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Nielsen J, Fejgin K, Sotty F, Nielsen V, Mørk A, Christoffersen CT, Yavich L, Lauridsen JB, Clausen D, Larsen PH, Egebjerg J, Werge TM, Kallunki P, Christensen KV, Didriksen M. Nielsen J, et al. Among authors: nielsen v. Transl Psychiatry. 2017 Nov 30;7(11):1261. doi: 10.1038/s41398-017-0011-8. Transl Psychiatry. 2017. PMID: 29187755 Free PMC article.
Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.
Nilsson SR, Fejgin K, Gastambide F, Vogt MA, Kent BA, Nielsen V, Nielsen J, Gass P, Robbins TW, Saksida LM, Stensbøl TB, Tricklebank MD, Didriksen M, Bussey TJ. Nilsson SR, et al. Among authors: nielsen j, nielsen v. Cereb Cortex. 2016 Oct;26(10):3991-4003. doi: 10.1093/cercor/bhw229. Epub 2016 Aug 9. Cereb Cortex. 2016. PMID: 27507786 Free PMC article.
In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders.
Grupe M, Bentzen BH, Benned-Jensen T, Nielsen V, Frederiksen K, Jensen HS, Jacobsen AM, Skibsbye L, Sams AG, Grunnet M, Rottländer M, Bastlund JF. Grupe M, et al. Among authors: nielsen v. Eur J Pharmacol. 2020 Nov 15;887:173440. doi: 10.1016/j.ejphar.2020.173440. Epub 2020 Aug 1. Eur J Pharmacol. 2020. PMID: 32745603
510 results