Structure of FAD-bound L-aspartate oxidase: insight into substrate specificity and catalysis.
Bossi RT, Negri A, Tedeschi G, Mattevi A.
Bossi RT, et al. Among authors: mattevi a.
Biochemistry. 2002 Mar 5;41(9):3018-24. doi: 10.1021/bi015939r.
Biochemistry. 2002.
PMID: 11863440
L-Aspartate oxidase (Laspo) catalyzes the conversion of L-Asp to iminoaspartate, the first step in the de novo biosynthesis of NAD(+). This bacterial pathway represents a potential drug target since it is absent in mammals. The Laspo R386L mutant was crystallized in the FA …
L-Aspartate oxidase (Laspo) catalyzes the conversion of L-Asp to iminoaspartate, the first step in the de novo biosynthesis of NAD(+). This …