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Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.
J Neurochem. 2014 Feb;128(4):536-46. doi: 10.1111/jnc.12481. Epub 2013 Nov 20.
J Neurochem. 2014.
PMID: 24117685
Free PMC article.
Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.
Wu J, Lou H, Alerte TN, Stachowski EK, Chen J, Singleton AB, Hamilton RL, Perez RG.
Wu J, et al. Among authors: alerte tn.
Neuroscience. 2012 Apr 5;207:288-97. doi: 10.1016/j.neuroscience.2012.01.028. Epub 2012 Jan 25.
Neuroscience. 2012.
PMID: 22326202
Free PMC article.
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Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.
Alerte TN, Akinfolarin AA, Friedrich EE, Mader SA, Hong CS, Perez RG.
Alerte TN, et al.
Neurosci Lett. 2008 Apr 11;435(1):24-9. doi: 10.1016/j.neulet.2008.02.014. Epub 2008 Feb 12.
Neurosci Lett. 2008.
PMID: 18314273
Free PMC article.
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Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.
Lou H, Montoya SE, Alerte TN, Wang J, Wu J, Peng X, Hong CS, Friedrich EE, Mader SA, Pedersen CJ, Marcus BS, McCormack AL, Di Monte DA, Daubner SC, Perez RG.
Lou H, et al. Among authors: alerte tn.
J Biol Chem. 2010 Jun 4;285(23):17648-61. doi: 10.1074/jbc.M110.100867. Epub 2010 Mar 31.
J Biol Chem. 2010.
PMID: 20356833
Free PMC article.
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