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Page 1
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Ting PC, Lee JF, Zorn N, Kim HM, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Ting PC, et al. Bioorg Med Chem Lett. 2013 Feb 15;23(4):985-8. doi: 10.1016/j.bmcl.2012.12.040. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23317570
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Zhou G, et al. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19. Bioorg Med Chem Lett. 2014. PMID: 24618302
Discovery of novel orally active ureido NPY Y5 receptor antagonists.
Li G, Stamford AW, Huang Y, Cheng KC, Cook J, Farley C, Gao J, Ghibaudi L, Greenlee WJ, Guzzi M, van Heek M, Hwa JJ, Kelly J, Mullins D, Parker EM, Wainhaus S, Zhang X. Li G, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1146-50. doi: 10.1016/j.bmcl.2007.11.132. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18160282
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.
Palani A, Rao AU, Chen X, Huang X, Su J, Tang H, Huang Y, Qin J, Xiao D, Degrado S, Sofolarides M, Zhu X, Liu Z, McKittrick B, Zhou W, Aslanian R, Greenlee WJ, Senior M, Cheewatrakoolpong B, Zhang H, Farley C, Cook J, Kurowski S, Li Q, van Heek M, Wang G, Hsieh Y, Li F, Greenfeder S, Chintala M. Palani A, et al. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. doi: 10.1021/ml200243g. eCollection 2012 Jan 12. ACS Med Chem Lett. 2011. PMID: 24900372 Free PMC article.
Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.
Qin J, Rao A, Chen X, Zhu X, Liu Z, Huang X, Degrado S, Huang Y, Xiao D, Aslanian R, Cheewatrakoolpong B, Zhang H, Greenfeder S, Farley C, Cook J, Kurowski S, Li Q, van Heek M, Chintala M, Wang G, Hsieh Y, Li F, Palani A. Qin J, et al. ACS Med Chem Lett. 2010 Dec 8;2(2):171-6. doi: 10.1021/ml100251u. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900295 Free PMC article.
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
Ahn HS, Bercovici A, Boykow G, Bronnenkant A, Chackalamannil S, Chow J, Cleven R, Cook J, Czarniecki M, Domalski C, Fawzi A, Green M, Gündes A, Ho G, Laudicina M, Lindo N, Ma K, Manna M, McKittrick B, Mirzai B, Nechuta T, Neustadt B, Puchalski C, Pula K, Zhang H, et al. Ahn HS, et al. J Med Chem. 1997 Jul 4;40(14):2196-210. doi: 10.1021/jm9608467. J Med Chem. 1997. PMID: 9216839
935 results